基础医学与临床 ›› 2015, Vol. 35 ›› Issue (1): 112-116.
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王蒙蒙1,刘卓琦2,王晟3,范瑞琦2,杨晓红1,罗达亚1
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摘要： 传统的miRNA-靶基因-生物学功能研究思路忽略了靶基因之间、靶基因所在信号通路之间的联系，使得miRNA调控作用的整体性与关联性无法得到全面的阐释。运用整体、系统且联系的思维方式，通过对荧光素酶报告实验验证的miR-205靶基因及其信号通路的整理和分析，将明确miR-205的研究方向，并为突破现有miRNA研究的整体格局，探索新颖的miRNA调控机制提供帮助。
关键词: miR-205, 靶基因, 研究进展与趋势
Abstract: Traditional research ideas of miRNA-target gene-biological function have ignored the contact between the target genes and signaling pathways they are involved, making the integrity and relevance of miRNA regulatory mechanisms not be fully elucidated. Integrated with systematic and relevant way of thinking, summarization and analysis for the luciferase reporter assay validated miR-205 target genes and their related signaling pathways will pave the way for new research area for miR-205, and, it will be helpful for breaking through the status quo and exploring the novel research areas for miRNA.
Key words: miR-205, target genes, research progress and trend
王蒙蒙 刘卓琦 王晟 范瑞琦 杨晓红 罗达亚. miRNA-205调控靶基因的研究进展与趋势[J]. 基础医学与临床, 2015, 35(1): 112-116.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2015/V35/I1/112
