基础医学与临床 ›› 2014, Vol. 34 ›› Issue (2): 257-261.

• 短篇综述 • 上一篇    下一篇

去分化用于细胞治疗的前景与展望

缪黄泰,聂绍平   

  1. 首都医科大学附属北京安贞医院,北京市心肺血管疾病研究所
  • 收稿日期:2013-05-06 修回日期:2013-06-21 出版日期:2014-02-05 发布日期:2014-01-13
  • 通讯作者: 聂绍平 E-mail:845583476@qq.com
  • 基金资助:
    国家自然科学基金面上项目;国家自然科学基金面上项目

The prospect of dedifferentiation for cell therapy

  • Received:2013-05-06 Revised:2013-06-21 Online:2014-02-05 Published:2014-01-13

摘要: 去分化是一种重要的细胞生物学现象,在体和离体环境下均可发生。去分化后得到的细胞具有未分化细胞的特征。去分化的过程较为复杂,涉及细胞自噬、细胞结构再循环等一系列生物学行为。越来越多的研究证实细胞去分化与细胞更新、组织再生和肿瘤发生等有着密切联系。

关键词: 去分化, 细胞治疗, 前景

Abstract: Dedifferentiation is an important life phenomenon in cell biology, which can be observed both in vivo and in vitro. The cells resulting from the dedifferentiation have the characteristics of undifferentiated cells. The process of dedifferentiation involving cell autophagy, recirculation of cells structure and a series of biological behavior is complex. More and more studies demonstrate the close relation between cell dedifferentiation and cell renewal, tissue regeneration and tumorigenesis, etc.

Key words: dedifferentiation, cell therapy, prospect