FBI-1基因在前列腺癌中的研究进展

基础医学与临床 ›› 2014, Vol. 34 ›› Issue (12): 1728-1731.

FBI-1基因在前列腺癌中的研究进展

张效通¹,段建敏²,王培龙³,巩进伟³

1. 兰州大学第二医院
2. 兰州大学第二附属医院泌尿外科
3. 兰州大学第二医院

收稿日期:2014-02-07 修回日期:2014-04-23 出版日期:2014-12-05 发布日期:2014-11-25
通讯作者: 段建敏 E-mail:djmurol@163.com

The research progress of FBI-1 gene in prostate cancer

Received:2014-02-07 Revised:2014-04-23 Online:2014-12-05 Published:2014-11-25

摘要/Abstract

摘要： 原癌基因FBI-1又称ZBTB7、LRF和Pokemon，其编码产物属于POK蛋白家族成员，具有转录抑制功能。过度表达的FBI-1可以通过其特殊的蛋白质结构组成抑制RB基因及ARF基因的表达，并且其在肿瘤的发生、发展及转归上具有重要作用。近年来，有很多医学机构对FBI-1基因与前列腺肿瘤进行了研究。原癌基因FBI-1有望成为肿瘤预防、诊断、治疗、预后评价的新靶标。

关键词: 原癌基因, FBI-1, 前列腺肿瘤

Abstract: The proto-oncogene FBI-1 is also called ZBTB7, LRF and Pokemon. Its encoding product belongs to the members of the family of POK protein and it has functions of transcriptional suppression. The overexpression of FBI-1 can repress the expression of Rb gene and ARF gene through its special protein structure. And it has played an important role in cancer’s occurrence, development and outcome. In recent years, many medical institutions have done researches about FBI-1gene in prostate cancer. The proto-oncogene FBI-1 might be a new target in cancer prevention, diagnosis, treatment and prognostic evaluation.

Key words: proto-oncogene, FBI-1, prostate neoplasms

中图分类号:

张效通段建敏王培龙巩进伟. FBI-1基因在前列腺癌中的研究进展[J]. 基础医学与临床, 2014, 34(12): 1728-1731.