乙二醛酶I在肝再生中的作用研究进展

基础医学与临床 ›› 2014, Vol. 34 ›› Issue (12): 1702-1705.

乙二醛酶I在肝再生中的作用研究进展

耿小芳¹,张富春¹,马纪¹,徐存拴²

1. 新疆大学生命科学与技术学院
2. 河南师范大学

收稿日期:2014-03-24 修回日期:2014-05-24 出版日期:2014-12-05 发布日期:2014-11-25
通讯作者: 徐存拴 E-mail:cellkeylab@126.com
基金资助:
国家973前期研究专项资助项目

Research progress of the role of glyoxalase I in liver regeneration

Received:2014-03-24 Revised:2014-05-24 Online:2014-12-05 Published:2014-11-25

摘要/Abstract

摘要： 代谢产生的毒性物质甲基乙二醛（MG）可通过乙二醛酶系转化成非毒性物质D-乳酸。再生肝等正常生理性增生以及肝癌等病理性增生组织中，乙二醛酶I（GLO1）的表达和活性增加，可提高肝脏的解毒能力和应激反应能力，促进肝细胞存活和增殖，保护肝脏细胞免受凋亡。

关键词: 肝再生, 甲基乙二醛, 乙二醛酶I, 细胞存活与增殖

Abstract: The glyoxalase system catalyses the conversion of deleterious methylglyoxal(MG), mainly produced by glycolysis, to non-toxic d-lactate. Increased glyoxalase I(GLO1) expression or enzymatic activity levels have been observed either in proliferating normal tissues such as regenerating liver, or in some proliferative disorders, including hepatocellular carcinoma, which can improve the ability of liver to detoxify and stress reaction, and promote hepatocyte survival and proliferation, and protect liver cells from apoptosis.

Key words: liver regeneration, methylglyoxal, glyoxalase I, cell survival and proliferation

中图分类号:

R333.3

耿小芳张富春马纪徐存拴. 乙二醛酶I在肝再生中的作用研究进展[J]. 基础医学与临床, 2014, 34(12): 1702-1705.