Notch信号通路对胶质瘤干细胞的调控作用研究进展

基础医学与临床 ›› 2014, Vol. 34 ›› Issue (11): 1566-1569.

Notch信号通路对胶质瘤干细胞的调控作用研究进展

陈声波,刘子豪,杜彬

暨南大学医学院病理教研室

收稿日期:2014-03-17 修回日期:2014-04-17 出版日期:2014-11-05 发布日期:2014-11-03
通讯作者: 杜彬 E-mail:tdubin@jnu.edu.cn
基金资助:
国家自然科学基金;暨南大学大学生创新创业训练计划

Advance on the mechanism of notch signaling pathway regulation on glioma stem cells

Received:2014-03-17 Revised:2014-04-17 Online:2014-11-05 Published:2014-11-03
Supported by:
the Chinese National Natural Science Foundation

摘要/Abstract

摘要： 胶质瘤干细胞（GSCs）是胶质瘤放化疗耐受和复发的重要原因。而Notch信号通路对GSCs形成、维持及胶质瘤患者放化疗耐受中起关键的调控作用。因此，深入研究GSCs中Notch信号通路调控机制对开发以该通路为靶向的治疗药物具有积极意义。

关键词: Notch信号, 胶质瘤干细胞, 抗治疗, 干细胞维持

Abstract: Glioma stem cells play a crucial role in glioma recurrence and resistance to therapies. Notch signaling pathway was involved in glioma stem cells' forming and maintaining. Moreover, Notch activation was contributed to chemotherapy and radiotherapy of resistance in glioma. Therefore, the study on Notch signaling pathway of glioma stem cells has positive significance for the development of targeted therapies.

Key words: notch signaling pathway, glioma stem cells, anti-therapy, stem cell maintenance

中图分类号:

R739.41

陈声波刘子豪杜彬. Notch信号通路对胶质瘤干细胞的调控作用研究进展[J]. 基础医学与临床, 2014, 34(11): 1566-1569.