基础医学与临床 ›› 2013, Vol. 33 ›› Issue (8): 1063-1066.
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沈亮
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摘要: 目前研究已证明抗菌肽是皮肤上阻止潜在病原体入侵的最直接力量,基础理论研究主要集中在阳离子抗菌肽的抗菌机制,阴离子抗菌肽涉及较少。抗菌肽对各种皮肤疾病的治疗作用和较低的细菌耐药性已经越来越明确,人工合成抗菌肽也具有光明的应用前景。但是在抗菌肽真正用于疾病治疗之前,必须需要解决一些技术上的障碍。
关键词: 生物活性肽, 抗菌肽, 皮肤病, 治疗
Abstract: Antimicrobial peptides have been shown to serve as immediate first-line defense against potential pathogens in the skin. The antibacterial mechanism of cationic antimicrobial peptides in skin disease process has been extensively studied,but anionic antimicrobial peptides is relatively unknown. The role of antimicrobial peptides in epidermal immunity and low predilection for developing bacterial resistance has been studied extensively thus far, the potential health benefits of the use of synthetic bioactive peptides is promising in dermatological disease. But some technical obstacles must be overcome before they can be successfully translated into therapeutics.
Key words: bioactive peptides, antimicrobial peptides, dermatology, therapeutics
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R751
沈亮. 抗菌肽在皮肤病治疗中的研究进展[J]. 基础医学与临床, 2013, 33(8): 1063-1066.
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