基础医学与临床 ›› 2013, Vol. 33 ›› Issue (8): 1024-1027.

• 研究论文 • 上一篇    下一篇

网织红细胞血红蛋白含量在筛查女性铁缺乏中的应用

徐二木1,罗丹2,徐佳1,吴卫3,迟书玲4,邱玲5   

  1. 1. 北京协和医院检验科生免室
    2. 空军总医院临床检验中心
    3. 中国医学科学院 北京协和医学院 北京协和医院
    4. 北京协和医院
    5. 中国医学科学院 北京协和医院
  • 收稿日期:2013-06-05 修回日期:2013-06-14 出版日期:2013-08-05 发布日期:2013-07-18
  • 通讯作者: 邱玲 E-mail:13901338944@163.com

Reticulocyte Hemoglobin Content in screening for iron deficiency in women

  • Received:2013-06-05 Revised:2013-06-14 Online:2013-08-05 Published:2013-07-18
  • Contact: Ling QIU E-mail:13901338944@163.com

摘要: 目的 探讨网织红细胞血红蛋白含量(CHr)在筛查女性铁缺乏中的应用意义。方法 选取体检中心506例女性体检者作为研究对象分为:铁缺乏组(无贫血缺铁组与缺铁性贫血组112例)与对照组(394例)。检测红细胞计数(RBC)、血红蛋白(HGB)、红细胞压积(HCT)、红细胞分布宽度(RDW)、血清铁蛋白(SF)、血清铁(SI)及CHr等指标。结果 铁缺乏组CHr为27.2 ± 3.0pg明显低于对照组的30.6 ±1.3pg,(P<0.001)。ROC曲线证实诊断女性铁缺乏CHr的曲线下面积为0.841,明显高于RBC、HGB、HCT、MCV、MCH、MCHC和RDW等指标,( P<0.05)。结论 CHr可以用于女性铁缺乏的筛查及早期诊断。

关键词: 关键词:网织红细胞, 铁缺乏, 贫血

Abstract: Objective To examine the utility of the reticulocyte hemoglobin content (CHr) in screening for iron deficiency in women. Methods 506 female subjects in department of medical examination were selected, and all the subjects were divided into iron deficiency group (iron deficiency without anemia group and iron deficiency anemia group, 121 cases), and healthy controls group(394 cases). The levels of red blood cell counting(RBC), hemoglobin(HGB), hematocrit(HCT), red blood cell volume distribution width(RDW), serum ferritin (SF), serum iron(SI), and CHr were determined. Results The levels of CHr(27.2 ± 3.0) in the iron deficiency group were significant lower than that (30.6 ±1.3) in the control group, P<0.001. Receiver operator characteristic curve analysis demonstrated that the area under the curve of CHr was 0.814 and significantly greater than RBC and HGB and HCT and MCV and MCH and MCHC and RDW in the diagnosis of iron deficiency in women, P<0.05. Conclusions CHr could be used for screening for and early diagnosis of iron deficiency in women.

Key words: KeyWords: reticulocyte, iron deficiency, anemia