MMP-9 R279Q基因多态性与冠心病易感性的Meta分析

基础医学与临床 ›› 2013, Vol. 33 ›› Issue (4): 467-471.

MMP-9 R279Q基因多态性与冠心病易感性的Meta分析

陈卫强¹,王浩然²,张健¹,齐向前¹

1. 泰达国际心血管病医院
2. 中国医学科学院北京协和医学院阜外心血管病医院

收稿日期:2012-04-19 修回日期:2012-06-28 出版日期:2013-04-05 发布日期:2013-03-15
通讯作者: 齐向前 E-mail:xiangqian.qi@utoronto.ca

MMP-9 R279Q polymorphism and susceptibility to coronary heart disease: A Meta-analysis

Received:2012-04-19 Revised:2012-06-28 Online:2013-04-05 Published:2013-03-15

摘要/Abstract

摘要： 目的探讨MMP-9 R279Q基因多态性与冠心病易感性的关系。方法检索PubMed，获取2012年1月1日以前发表的MMP-9 R279Q基因多态性与冠心病易感性的病例-对照研究。以冠心病组与对照组人群基因型分布的OR值及95%CI为效应指标，在纯合子比较模型、显性模型和隐性模型中采用固定效应方法进行合并分析, 并进行偏倚评估，应用STATA11.0软件进行统计学处理。结果共纳入文献5篇，在MMP-9 R279Q多态性位点，基因型比较模型中合并OR值为0.925 (95% CI = 0.847-1.009)，纯合子比较模型合并OR值为0.866 (95% CI = 0.713-1.052)，显性模型合并OR值为0.909 (95% CI = 0.809-1.020)，隐性模型合并OR值为0.902 (95% CI = 0.750-1.086)。结论 MMP-9 R279Q基因多态性可能与冠心病易感性无关。

关键词: MMP, 冠心病, 基因多态性, Meta分析

Abstract: Objective To investigate the relationship between matrix metalloproteinase-9 (MMP-9) gene polymorphism and genetic susceptibility to coronary heart disease. Methods A Meta-analysis on MMP-9 R279Q polymorphism and susceptibility to coronary heart disease was performed by searching for studies included in PubMed before January 1, 2012. For each study, odds ratios (ORs) and 95% confidence intervals (CIs) was calculated to assume homozygote comparison, dominant and recessive genetic models. Pooled ORs and 95% CIs was calculated and publication bias was assessed. All statistical analyses were conducted by STATA 11.0 software. Results A total of 5 case-control studies were analyzed in the study. The MMP-9 R279Q QQ genotype was not associated with the risk of coronary heart disease compared with R279Q RR genotype (QQ vs. RR: OR=0.866; 95%CI=0.713-1.052). Effect estimates from a dominant model [(QQ + RQ) vs. RR: OR= 0.909; 95%CI=0.809-1.020] or a recessive model [QQ vs. (RQ + RR):OR=0.902; 95%CI=0.750-1.086] suggest that the MMP-9 R279Q variants are not associated with coronary heart disease risk. Conclusion MMP-9 R279Q gene polymorphism may not be associated with genetic susceptibility to coronary heart disease.

Key words: MMP, Coronary heart disease, Gene polymorphism, Meta-analysis

中图分类号:

陈卫强王浩然张健齐向前. MMP-9 R279Q基因多态性与冠心病易感性的Meta分析[J]. 基础医学与临床, 2013, 33(4): 467-471.

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