应用iPSC技术构建疾病模型的研究进展

基础医学与临床 ›› 2013, Vol. 33 ›› Issue (12): 1626-1629.

应用iPSC技术构建疾病模型的研究进展

刘文博,傅歆,肖苒

中国医学科学院整形外科医院

收稿日期:2013-01-24 修回日期:2013-03-27 出版日期:2013-12-05 发布日期:2013-11-28
通讯作者: 肖苒 E-mail:xiaoran@pumc.edu.cn
基金资助:
国家自然科学基金面上项目

Application of iPSC technique in disease modeling

Wen-bo liu¹,XIN FURan XIAO

Received:2013-01-24 Revised:2013-03-27 Online:2013-12-05 Published:2013-11-28
Contact: Ran XIAO E-mail:xiaoran@pumc.edu.cn

摘要/Abstract

摘要： 诱导多能干细胞（iPSC）技术用于构建体外疾病模型的基本步骤是：诱导体细胞重编程为亚全能干细胞，再将这些细胞分化为相关疾病的受累细胞亚型，模拟疾病特征并重建病理过程，为研发治疗方法提供资料。

关键词: 诱导多能干细胞, 疾病模型

Abstract: The procedure of employing induced pluripotent stem cell (iPSC) technology for in vitro disease modeling is as follow: 1) generation of patient-specific iPSCs; 2) characterization of iPSCs; 3) differentiation of iPSCs into disease-relevant subtypes; 4) utilization of iPSCs and subtypes to recapitulate features and development of the original disease; 5) pharmacological interventions.

Key words: induced pluripotent stem cell, disease modeling

中图分类号:

刘文博傅歆肖苒. 应用iPSC技术构建疾病模型的研究进展[J]. 基础医学与临床, 2013, 33(12): 1626-1629.

Wen-bo liu XIN FU Ran XIAO. Application of iPSC technique in disease modeling[J]. Basic & Clinical Medicine, 2013, 33(12): 1626-1629.

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