基础医学与临床 ›› 2013, Vol. 33 ›› Issue (12): 1560-1563.

• 研究论文 • 上一篇    下一篇

黑龙江省健康青少年血清肌酐参考范围的建立

程歆琦1,程倩1,邱玲2,刘茜1,刘荔1,徐成丽3,朱广瑾4   

  1. 1. 中国医学科学院北京协和医院
    2. 中国医学科学院 北京协和医院
    3. 中国医学科学院 基础医学研究所 北京协和医学院 基础学院
    4. 中国医学科学院基础医学研究所 北京协和医学院基础学院
  • 收稿日期:2013-04-19 修回日期:2013-10-17 出版日期:2013-12-05 发布日期:2013-11-28
  • 通讯作者: 朱广瑾 E-mail:zhugj@126.com
  • 基金资助:
    科技部科技基础性工作专项项目资助课题

Establishing serum creatinine reference intervals of healthy adolescents in Heilongjiang province

  • Received:2013-04-19 Revised:2013-10-17 Online:2013-12-05 Published:2013-11-28
  • Contact: Guang-jin ZHU E-mail:zhugj@126.com

摘要: 目的 调查分析黑龙江省健康青少年血清肌酐(Cr)水平,建立不同性别和不同年龄健康青少年血清Cr的参考范围。方法 采用分层、随机整群抽样的大样本临床流行学调查,于2008年7月至2009年6月,从黑龙江省哈尔滨和牡丹江的市区、郊区随机抽取2281名8~18岁健康中小学生进行体检,采集受试者清晨空腹静脉血并分离血清,测定血清Cr浓度。筛除离群数据个体后,共2 276名受试者入选,男1 039名,女1 237名,其中汉族1 392名,朝鲜族884名。建立不同性别、不同年龄健康青少年血清Cr的参考范围(P2.5~P97.5)。结果 全部调查人群按<11岁、11~12岁、13~14岁、15~16岁和17~18岁进行分组,其中男性Cr的参考范围分别是35~60、39~70、45~81、54~88和60~98μmol/L;女性Cr的参考范围分别是34~59、37~59、39~70、43~69和43~74μmol/L。Cr随年龄增加而升高,男性高于女性(P<0.001)。不同民族之间Cr无差异。结论 初步建立了黑龙江省健康青少年血清Cr的参考范围,对临床医生特别是儿科医生判断和评估8~18岁年龄段患者的肾功能有很好的参考价值。

关键词: 健康青少年, 朝鲜族, 肌酐, 参考范围

Abstract: Objective To analyze the serum creatinine level among apparently healthy adolescents in Heilongjiang Province and establish the reference intervals of serum creatinine in different gender and different age groups of adolescents. Methods Large sample clinical epidemiological investigation was applied by two-stage clustering sampling method. Random sample of 2 281 primary and secondary school students from 8 to 18-year-old was selected from different district of Heilongjiang Province including Harbin and Mudanjiang from July 2008 to June 2009. The fasting venous blood was collected and serum was separated, then serum creatinine concentration was measured as soon as possible. After screening outlier individual, a total of 2 276 subjects were enrolled involving 1 039 male and 1 237 female, of which 1 392 Han and 884 Chinese Korean. Percentile was used to describe the distribution of serum Cr level of different growth stages and the reference intervals of serum Cr for adolescents were established by gender and age (P2.5 to P97.5). Results The reference intervals of creatinine for <11, 11~12, 13~14, 15~16, and 17~18 year-old males were 35~60、39~70、45~81、54~88、60~98μmol/L respectively while for females were 35~60、39~70、45~81、54~88、60~98μmol/L respectively. The concentration of Cr increased with age and was higher in Males than in Females(P<0.001). No difference of Cr level was seen between Chinese Han and Chinese Korean. Conclusion The reference intervals of serum creatinine for healthy adolescents in Heilongjiang Province are established, which supply good reference value for clinicians, especially pediatricians to judge and assess renal function in patients 8 to 18 years of age.

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