关键词: 诱导性多能干细胞, 转化医学, 信息分析

Abstract: Object To analyze the current status，main research area of iPSCs and its translational medicine research. Methods the study conducts a bibliometric analysis of iPSCs by collecting 2859 papers from Web of Science (WOS) in the period of 2006-2013, combining ClinicalTrials datababse with Cortellis for Competitive Intelligence to analyze the clinical trial and drug development of iPSCs. Results The number of iPSCs papers is published with rapid increasing of 159% per year. According to the number of papers, citations per paper and relative advance index, USA and Japan are the world leading in iPSCs area. Based on the number of published papers, Chinese Academy of Sciences and Shanghai Jiaotong University rank the top 20 institution in the world, but their citations per paper and relative advance index both under the average level of the global. The percent of funding supported papers increases from 36% in 2008 o 81% in 2012. Influencing factors of reprogramming and application study is the hot area in iPSCs, and drug development and regenerative medicine are the priorities in translation medicine. Conclusion From bench study to clinical application is the necessary direction in iPSCs, and its security is the primary issue to be solved in translational research.

Key words: induced pluripotent stem cells, translational medicine, information analysis