基础医学与临床 ›› 2013, Vol. 33 ›› Issue (10): 1337-1340.
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廖锋1,郑扬2,耿彬2,唐朝枢3
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摘要: 较低的成骨效率限制间充质干细胞移植用于临床治疗骨科疾病。通过阻断凋亡通路、激活磷酸肌醇-3激酶/蛋白激酶B等信号转导分子、补充生长因子或改善支架血供等多种方法,促进植入体内的间充质干细胞存活、归巢和定向分化,可提高其成骨效率。
关键词: 间充质干细胞, 移植, 成骨
Abstract: Lower homing, surviving, proliferation, differentiation and osteogenesis of transplanted mesenchymal stem cells (MSCs) limit its use in bone disease. Recently, transplantation in combination with growth factors, prevascularized scaffolds, or regulation of signaling proteins and cytoprotective genes was applied to increase its therapeutic effects, and the results are encouraging.
Key words: mesenchymal stem cells, transplantation, osteogenesis
中图分类号:
R336
廖锋 郑扬 耿彬 唐朝枢. 促进移植间充质干细胞成骨的研究进展[J]. 基础医学与临床, 2013, 33(10): 1337-1340.
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