血管紧张素转化酶基因I/D多态性与脑梗死后抑郁相关

基础医学与临床 ›› 2012, Vol. 32 ›› Issue (9): 1040-1043.

血管紧张素转化酶基因I/D多态性与脑梗死后抑郁相关

杜明艳¹,丁文军²,封靖¹,杜会山¹

1. 潞河医院
2. 中国科学院研究生院

收稿日期:2012-05-21 修回日期:2012-07-03 出版日期:2012-09-05 发布日期:2012-08-28
通讯作者: 杜明艳 E-mail:my_du@sina.com
基金资助:
国家科技支撑计划

Association between the Angiotensin-Converting Enzyme Gene I/D polymorphism and Post-cerebral Infarction Depression

Received:2012-05-21 Revised:2012-07-03 Online:2012-09-05 Published:2012-08-28
Contact: Ming-Yan DU E-mail:my_du@sina.com
Supported by:
The National Key Technology R&D Program

摘要/Abstract

摘要： 目的探讨北京地区汉族人群血管紧张素转化酶（ACE）基因插入/缺失（I/D）多态性与脑梗塞后抑郁（PCID）发病的关系。方法用汉密尔顿抑郁量表评定664例脑梗塞患者抑郁状态，用PCR方法检测患者ACE基因I/D多态性，分析基因多态性分布与脑梗塞后抑郁发病的相关性。结果脑梗塞后抑郁患者组ACE基因的I/I基因型频率和I等位基因频率（分别为0.388和0.549）显著高于脑梗塞后非抑郁患者对照组（C）（分别为0.286和0.481，P<0.05）。结论 ACE基因I/D多态性与脑梗塞后抑郁发病相关，ACE I/I基因型可能是脑梗塞后抑郁发病的危险因素。

关键词: 脑梗塞后抑郁, 血管紧张素转化酶, 基因多态性

Abstract: Abstract：Objective To explore the association between the angiotensin-converting enzyme（ACE）gene I/D polymorphism and post-cerebral infarction depression（PCID）．Methods The ACE gene I/D polymorphism was detected in a study of 664 cerebral infraction cases, 286 post-cerebral infarction depression cases and 378 control cases without depression after cerebral infarction were classified. The association of gene polymorphism and post-cerebral infarction depression was evaluated. Results The genotype frequencies of ACE gene I/I and I allete in the PCID group（0.388 and 0.549） were significantly higher than those in the control group （0.286 and 0.481）. Conclusions These results suggest that ACE gene I/I variant is significantly associated with post-cerebral infarction depression.

Key words: angiotensin-converting enzyme, gene polymorphism, post-cerebral infarction depression

杜明艳丁文军封靖杜会山. 血管紧张素转化酶基因I/D多态性与脑梗死后抑郁相关[J]. 基础医学与临床, 2012, 32(9): 1040-1043.

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