六价铬污染与健康损害研究进展

基础医学与临床 ›› 2012, Vol. 32 ›› Issue (8): 974-978.

六价铬污染与健康损害研究进展

杨阳,许群

北京协和医学院基础医学院

收稿日期:2011-12-29 修回日期:2012-03-26 出版日期:2012-08-05 发布日期:2012-07-17
通讯作者: 许群 E-mail:xuqun66@yahoo.com.cn

Progress in hexavalent chromium pollution and health damage

Received:2011-12-29 Revised:2012-03-26 Online:2012-08-05 Published:2012-07-17

摘要/Abstract

摘要： 六价铬被国际癌症研究机构（International Agency for Research on Cancer，IARC）确认为人类致癌物，这一界定主要是基于经呼吸途径暴露后，实验动物及职业人群中观察到癌症发生率显著升高所致。但是，目前经消化道途径暴露于六价铬污染的健康影响方面的研究证据有限。该文综述了最新的六价铬经消化道摄入途径暴露后,对消化系统肿瘤、骨骼系统发育、血液系统及组织浸润的影响，也包括六价铬在肝肾组织分布，经皮肤直接接触后的影响及铬在体内代谢的分子机制。

关键词: 六价铬,健康损害

Abstract: Hexavalent chromium is classified as human carcinogens, based on increased incidences of lung cancers in animals and occupational people after inhalation exposures. However, it is limited that the current health effect research which focus on the digested tract of exposure to Hexavalent chromium pollution. This paper reviewed the latest exposures to hexavalent chromium through ingestion, the digestive system tumors, the impact of development on the skeletal system, blood system effects and tissue infiltration, tissue distribution of hexavalent chromium in the liver and kidney, the skin after direct contact impact, and molecular mechanism of chromium metabolism.

Key words: Hexavalent chromium , health damage

杨阳许群. 六价铬污染与健康损害研究进展[J]. 基础医学与临床, 2012, 32(8): 974-978.