基础医学与临床 ›› 2012, Vol. 32 ›› Issue (11): 1364-1366.

• 短篇综述 • 上一篇    下一篇

转化生长因子β与炎性反应肠病相关肠纤维化的关系

李辉,宋佳,张晓岚   

  1. 河北医科大学第二医院
  • 收稿日期:2012-03-09 修回日期:2012-05-07 出版日期:2012-11-05 发布日期:2012-10-19
  • 通讯作者: 李辉 E-mail:lihhuilhlh@163.com

The relationship between transforming growth factor-β and inflammatory bowel disease associated intestinal fibrosis

  • Received:2012-03-09 Revised:2012-05-07 Online:2012-11-05 Published:2012-10-19

摘要: 转化生长因子β(TGF-β)在细胞生长分化、血管发生、伤口修复等生理过程中发挥至关重要的作用。在炎性反应肠病(IBD)发病过程中,TGF-β能够促进间质细胞增殖、迁移和聚集,增加细胞外间质(ECM)的合成进而诱导肠道纤维化的发生。

关键词: 肠道纤维化, 转化生长因子β, 炎症性肠病, 克罗恩病, 溃疡性结肠炎

Abstract: Transforming growth factor-β (TGF-β) plays a central role in physiological function including cell growth and differentiation, angiogenesis, wound healing, and so on. In the process of inflammatory bowel disease (IBD), TGF-β can promote mesenchymal cell proliferation, migration, accumulation and increase production of extracellular matrix (ECM) components, then, induce the development of intestinal fibrosis.

Key words: intestinal fibrosis, transforming growth factor-β, inflammatory bowel disease, Crohn's disease, ulcerative colitis

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