基础医学与临床 ›› 2012, Vol. 32 ›› Issue (11): 1364-1366.
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李辉,宋佳,张晓岚
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摘要: 转化生长因子β(TGF-β)在细胞生长分化、血管发生、伤口修复等生理过程中发挥至关重要的作用。在炎性反应肠病(IBD)发病过程中,TGF-β能够促进间质细胞增殖、迁移和聚集,增加细胞外间质(ECM)的合成进而诱导肠道纤维化的发生。
关键词: 肠道纤维化, 转化生长因子β, 炎症性肠病, 克罗恩病, 溃疡性结肠炎
Abstract: Transforming growth factor-β (TGF-β) plays a central role in physiological function including cell growth and differentiation, angiogenesis, wound healing, and so on. In the process of inflammatory bowel disease (IBD), TGF-β can promote mesenchymal cell proliferation, migration, accumulation and increase production of extracellular matrix (ECM) components, then, induce the development of intestinal fibrosis.
Key words: intestinal fibrosis, transforming growth factor-β, inflammatory bowel disease, Crohn's disease, ulcerative colitis
中图分类号:
R363.2
李辉 宋佳 张晓岚. 转化生长因子β与炎性反应肠病相关肠纤维化的关系[J]. 基础医学与临床, 2012, 32(11): 1364-1366.
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