阿立哌唑与坦度螺酮联合应用改善女性精神分裂症患者认知功能

基础医学与临床 ›› 2012, Vol. 32 ›› Issue (11): 1318-1321.

阿立哌唑与坦度螺酮联合应用改善女性精神分裂症患者认知功能

刘洁¹,白录东²,徐成敏²,李大江³

1. 山东大学医学院
2. 山东省精神卫生中心
3. 乳山市康宁医院

收稿日期:2011-09-30 修回日期:2012-03-29 出版日期:2012-11-05 发布日期:2012-10-19
通讯作者: 徐成敏 E-mail:xu_chengmin@163.com

Aripiprazole Combing Tandospirone can Improve Cognitive Function of Female Schizophrenic Patients

Received:2011-09-30 Revised:2012-03-29 Online:2012-11-05 Published:2012-10-19

摘要/Abstract

摘要： 目的探讨阿立哌唑和坦度螺酮联用对女性精神分裂症患者认知功能的影响。方法 91例女性精神分裂症患者随机分成两组，实验组（阿立哌唑联用坦度螺酮）47例，对照组（阿立哌唑）44例，治疗8周，在治疗前后采用阳性与阴性症状量表PANSS评定临床疗效，采用威斯康星卡片分类测验WCST以及注意广度测验评定认知功能，采用副作用量表TENSS评定不良反应。结果治疗后两组PANSS评分较治疗前显著下降，（P﹤0.01）。治疗后两组认知症状均有所改善。实验组认知测验中言语记忆、数字序列、持续操作、完成分类数高于对照组（P﹤0.05或0.01），错误应答数、非持续错误数低于对照组（P﹤0.05或0.01）。两组不良反应轻微，对照组患者出现震颤的例数显著增多（P﹤0.05）。结论阿立哌唑联合坦度螺酮治疗精神分裂症可有效改善精神分裂症患者的认知功能。

关键词: 精神分裂症, 认知功能, 阿立哌唑, 坦度螺酮

Abstract: Objective To explore the effect of aripiprazole combing tandospirone in cognitive function of schizophrenic patients. Method Ninety-one patients with schizophrenia were randomly divided into the controlled group(aripiprazole combing tandospirone n=47)and the matched group (aripiprazole n=44). Clinical efficacy was evaluated by Positive and Negative Symptoms Scale(PANSS)at baseline and 8 weeks. Cognitive function was assessed by Wisconsion Card Sorting Test(WCST)and Attention span test. Results The effect of these two groups has improved greatly, (P﹤0.01), At the end of the 8th week, verbal memory, sequence of number, continuous operation, categories completed improved more significantly compared with patients without tandospirone,( P﹤0.05 or 0.01). Response errors and non-persistent errors lower than patients without tandospirone, (P﹤0.05 or 0.01).The adverse reaction of the two group is few. Many patient without tandospirone caused tremor, which showed great significant differences(P﹤0.05). Conclusion Aripiprazole combing Tandospirone can improve cognitive function of female schizophrenic patients.

Key words: schizophrenia, cognitive function, aripiprazole, tandospirone

中图分类号:

R749.053

刘洁白录东徐成敏李大江. 阿立哌唑与坦度螺酮联合应用改善女性精神分裂症患者认知功能[J]. 基础医学与临床, 2012, 32(11): 1318-1321.

[1]	王前刘丽梅林永忠. 阻塞性睡眠呼吸暂停综合征患者轻度认知功能障碍的MoCA评估[J]. 基础医学与临床, 2015, 35(7): 956-958.
[2]	王萌纪汶君陈莉娜. 糖尿病性认知功能障碍研究进展[J]. 基础医学与临床, 2015, 35(2): 240-243.
[3]	马楼艳张栋珉张颖高原柴李殷赵柯湘夏丽肖谦. Ghrelin对糖尿病大鼠海马神经元凋亡及其认知功能的影响 [J]. 基础医学与临床, 2011, 31(6): 672-678.