Abstract: The global medical education has experienced about-100-year development, and achieved greatly, but it hasn’t completely met the needs of the health system and the populations. Consequently, the Commission on Education of Health Professionals for the 21st Century calls for the global medical education system to move the medical education in the world into the third generation reform——Systems-based Education. In this paper, we compare the medical education between the mainland in China and the United States, analyze the differences of the educational programs、curriculum designing、evaluation system、management system between the two countries, and then introduce the 3 future educational measures in America, to provide reference for our educators and welcome the third generation reform.