血清SCCA水平及盆腔淋巴结HPV 16/18感染状况与宫颈鳞癌患者预后的关系

基础医学与临床 ›› 2012, Vol. 32 ›› Issue (10): 1167-1170.

血清SCCA水平及盆腔淋巴结HPV 16/18感染状况与宫颈鳞癌患者预后的关系

曾四元,梁美蓉,李隆玉,刘晖,钟美玲,魏晚霞

江西省妇幼保健院

收稿日期:2011-11-14 修回日期:2012-03-05 出版日期:2012-10-05 发布日期:2012-09-28
通讯作者: 梁美蓉 E-mail:joysinsummer920@tom.com
基金资助:
血清SCCAg水平检测在宫颈鳞癌中的临床意义

The relation of serum squamous cell carcinoma antigen level, pelvic lymph node HPV16/18 infection in patients with cervical squamous cell carcinoma and its prognosis

Received:2011-11-14 Revised:2012-03-05 Online:2012-10-05 Published:2012-09-28

摘要/Abstract

摘要： 摘要：目的探讨术前血清SCCA水平、盆腔淋巴结HPV16/18感染状况与宫颈鳞癌患者预后的关系。方法 ELISA法检测血清SCCA水平，实时荧光定量PCR法检测盆腔淋巴结HPV16 /18感染，分析二者与宫颈鳞癌患者三年生存率的关系。结果血清SCCA水平与盆腔淋巴结HPV16/18感染相关 (P<0.05)。35例宫颈鳞癌患者中位随访36个月（12～41月），死亡4例，3年总体生存率为85.0%。血清SCCA阴性者和阳性者的3年生存率分别为100%和69.2%；盆腔淋巴结HPV16/18阴性者和阳性者的3年生存率分别为96.4%和57.1%；血清SCCA及盆腔淋巴结HPV16/18阴性患者的3年生存率明显优于阳性者（P<0.05）。淋巴结转移、血清SCCA和淋巴结HPV16/18与宫颈鳞癌患者的预后相关。结论血清SCCA水平及盆腔淋巴结HPV 16/18感染状况与宫颈鳞癌患者预后相关，可作为宫颈鳞癌预后判断指标。

关键词: 宫颈肿瘤, 鳞状细胞癌抗原, 人乳头瘤病毒, 预后

Abstract: Abstract: Objective the study aimed to explore the relation of preoperative serum SCCA levels, pelvic lymph node HPV16/18 infection in patients with cervical squamous cell carcinoma and its prognosis. Methods ELISA was performed to detect the SCCA level and real-time fluorescence quantitative PCR was utilized to analyze the pelvic lymph node HPV16 / 18 positive rate. The relation of SCCA level, HPV16/18 positive rate and the three-year survival rate was investigated. Results The SCCA level is closely related with the infection of HPV16/18 in pelvic lymph node (P<0.05).The media follow-up time for 35 patients with cervical squamous cell carcinoma was 36 m(rang 12 m-41 m). Four patients were dead and the overall 3 year survival rate was 85.0%. The 3 year survival rates for patients with positive SCCA and negative SCCA were 100% and 69.2% respectively and that were 96.4% and 57.1% for patients with positive pelvic lymph node HPV16/18 and negative pelvic lymph node HPV16/18. the 3 year survival rates for patients with negative SCCA and lymph node HPV16/18 were obviously better than that of positive ones（P<0.05). lymph node metastasis, SCCA level and pelvic lymph node HPV16/18 infectionstatus were associated with prognosis. Conclusion SCCA level and pelvic lymph node HPV16/18 infection status were associated with the prognosis of cervical squamous carcinoma patients and could be the prognostic markers for cervical squamous carcinoma.

Key words: cervical neoplasms, squamous cell carcinoma antigen, human papillomavirus, prognosis

曾四元梁美蓉李隆玉刘晖钟美玲魏晚霞. 血清SCCA水平及盆腔淋巴结HPV 16/18感染状况与宫颈鳞癌患者预后的关系[J]. 基础医学与临床, 2012, 32(10): 1167-1170.

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