关键词: 进展期胃癌, CIK细胞, 过继免疫疗法

Abstract: Objective Evaluate the clinical efficacy and secruity of CIK cell union chemotherapy for adanced gastric cancer after operation. Methods Choose 76 patients who suffered from adanced gastric cancer, divide them into CIK cell and chemotherapy union treatment group and the pure chemotherapy group. Patients with the blood culture and infusion processe are observed the security of CIK cell infusion, analyse and detect T lymphocyte subsets in vivo with FCM, compare its short-term clinical curative effect and their cancer-free survival time and overall survival time between the two groups with log - rank inspection. Results In the process of autologous CIK cell treatment, some cases appear the symtoms of slight fever, nausea, vomiting, not appear evident adverse reactions. CD4 + / CD8+ ratio increases after CIK cell infusion, NK expression increased (P < 0.05). In terms of short-term clinical curative effect, the objective effective ratio and the disease control ratio in chemotherapy union treatment group and CIK are hither than those in the pure chemotherapy group (41.03% vs 18.92%，61.54% vs 56.76%), (P < 0.05). The survival time of median cancer-free patients in pure chemotherapy group after operation are shorter than those of the union therapy group (P < 0.05). Patient’s postoperation median survival time was 36 months in pure chemotherapy group, Patients in union group, 39 months. Conclusion The technique of CIK cell and chemotherapy union therapy is effective,it can improve patient’s immunity, it can also make the patient's cancer-free survival time longer.