基础医学与临床 ›› 2011, Vol. 31 ›› Issue (12): 1402-1405.
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马守成
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摘要： DNA 错配修复系统（MMR）负责监视和改正在微卫星DNA序列中出现的碱基错配，这个系统出现问题时将导致DNA序列中微卫星序列的不稳定性（MSI）或编码功能蛋白的基因突变，从而引发肿瘤。本文就MMR系统与临床肿瘤的分子机理研究现状，作一综述。
关键词: MMR MSI , 结直肠肿瘤 , 乳腺肿瘤 , 前列腺肿瘤 , 神经胶质瘤
Abstract: Mismatch repair (MMR) is a critical mechanism for maintaining microsatellite stability through the correction of base substitution mismatches and insertion/deletion events. Dysfunction of this system will lead to microsatellite stability (MSI), or mutated genes that code functional proteins, thus give rise to cancer. Here we will give an overview for the MMR and the molecular mechanism of related clinical cancer.
Key words: MMR MSI, HNPCC (CRC), Breast cancer, Prostate cancer, Glioma
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马守成. DNA错配修复和临床肿瘤新进展 [J]. 基础医学与临床, 2011, 31(12): 1402-1405.
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链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2011/V31/I12/1402
