基础医学与临床 ›› 2010, Vol. 30 ›› Issue (8): 882-884.

• 短篇综述 • 上一篇    下一篇

液压转基因技术

邢雪琨 徐存拴   

  1. 河南师范大学生命科学学院
  • 收稿日期:2009-05-31 修回日期:2009-09-19 出版日期:2010-08-05 发布日期:2010-08-05

Hydrodynamic gene delivery

Xue-kun XING, Cun-shuan XU   

  1. .College of Life Science,Henan Normal University
  • Received:2009-05-31 Revised:2009-09-19 Online:2010-08-05 Published:2010-08-05

摘要: 外源基因靶向进入动物体内并高效表达是研究基因功能和进行基因治疗的基础。近几年建立的液压转基因技术能简便、快速、安全、高效地将质粒靶向导入动物体内,并能在靶部位高效、稳定表达。本文介绍了液压转基因技术概念、机理及其应用等。

关键词: 尾静脉液压转基因技术, 器官靶向性, 基因功能, 基因治疗

Abstract: Foreign gene targeting transfection into vivo and highly expression are the fundation of investigating gene function and gene therapy. The hydrodynamics-based transfection founded in recent years can deliver plasmid into animal cells conveniently, quickly, safely, efficiently, and gene can highly, stably express. This paper introduces the concept, mechanism and application of hydronamic gene delivery.

Key words: hydronamics-based tail-vein transgene technology, orgain targeting, gene function, gene therapy

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