SPINK家族与人类疾病

基础医学与临床 ›› 2010, Vol. 30 ›› Issue (5): 550-553.

SPINK家族与人类疾病

李海深曹云钱朝南

中山大学肿瘤防治中心中山大学肿瘤防治中心

收稿日期:2009-05-08 修回日期:2009-06-27 出版日期:2010-05-05 发布日期:2010-05-05
通讯作者: 钱朝南

Kazal-type Serine Protease Inhibitors and Human Diseases

Hai-shen LI, Yun CAO, Chao-nan QIAN

Sun Yat-sen University Cancer Center Sun Yat-sen University Cancer Center

Received:2009-05-08 Revised:2009-06-27 Online:2010-05-05 Published:2010-05-05
Contact: Chao-nan QIAN

摘要/Abstract

摘要： 丝氨酸蛋白酶抑制物Kazal型（Serine protease inhibitor kazal type , SPINK）家族与慢性胰腺炎、Netherton 综合征、食管癌等疾病关系密切。目前对SPINK1、SPINK5、SPINK7等亚族的研究比较清楚，其他一些亚族还有待深入研究。本文综述了SPINK家族的基因定位、蛋白质结构、生理功能以及与人类疾病的关系。

关键词: SPINK家族, 慢性胰腺炎, Netherton Syndrome, 食管癌

Abstract: The family of Kazal-type serine protease inhibitor (SPINK) correlates with chronic pancreatitis, Netherton syndrome, esophageal carcinoma, and other humane diseases. The functions of SPINK1, SPINK5 and SPINK7 have been identified. However, other members remain to be explored. In this review, we summarized locations of SPINK genes, protein structures, functions of SPINK proteins, and the relationship between SPINK family and humane diseases.

Key words: SPINK, Chronic Panceatitis, Netherton Syndrome, Esophageal Carcinoma

中图分类号:

R735.2

李海深曹云钱朝南. SPINK家族与人类疾病[J]. 基础医学与临床, 2010, 30(5): 550-553.

Hai-shen LI; Yun CAO; Chao-nan QIAN. Kazal-type Serine Protease Inhibitors and Human Diseases[J]. Basic & Clinical Medicine, 2010, 30(5): 550-553.

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