基础医学与临床 ›› 2010, Vol. 30 ›› Issue (5): 547-549.

• 短篇综述 • 上一篇    下一篇

间充质干细胞在T细胞免疫反应中的调节作用

蒋志琼 唐中 袁国华 谭竟   

  1. 川北医学院附属医院 川北医学院附属医院
  • 收稿日期:2009-06-03 修回日期:2009-10-09 出版日期:2010-05-05 发布日期:2010-05-05
  • 通讯作者: 唐中

Immune regulatory effect of masenchymal stem cells on T lymphocyte

Zhi-qiong JIANG, Zhong TANG, Guo-hua YUAN, Jing TAN   

  1. Affiliated Hospital of North Sichuan Medical College Affiliated Hospital of North Sichuan Medical College
  • Received:2009-06-03 Revised:2009-10-09 Online:2010-05-05 Published:2010-05-05
  • Contact: Zhong TANG,

摘要: 间充质干细胞(MSCs)独特的免疫调节作用以T细胞为主,在混合淋巴细胞反应中,通过周期阻滞抑制T细胞增殖,但不引起T细胞凋亡增加、活化受抑。同时MSCs还能降低反应体系中的CD8+T细胞和Th1细胞,升高Th2细胞以抑制炎症反应,从而在T细胞介导的自身免疫性疾病中发挥治疗作用。

关键词: 间充质干细胞, T细胞, 免疫调节

Abstract: Mesenchymal stem cells (MSCs) have a unique role in immune regulation based on T-cells. On the mixed lymphocyte reactions, MSCs have inhibited T-cells proliferation by the effect of cycle arrest, but they do not cause the increase of T-cells apoptosis and the suppression of T-cells activation. In addition, MSCs can reduce CD8+ T cells and Th1 cells, and simultaneously increase Th2 cells in the reaction system to suppress the inflammatory response, which may play a therapeutic effect on the T-cells mediated autoimmune diseases.

Key words: Mesenchymal stem cells, T lymphocytes, Immunoregulation

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