关键词: 抽动秽语综合症, 自身抗体, 抗链“O”, 可溶性白细胞介素6受体, 可溶性gp130

Abstract: Objective: To explore the mechanism underlying the immunologic injury in TS patients. Methods: The serum levels of anti-brain antibody（ABAb）, antinuclear antibody（ANAb）, soluble IL-6 receptor (sIL-6R), and soluble gp130 (sgp130) in patients with TS were analyzed by commercialized ELISA kits,and the titer of anti-streptolysin O (ASO) in TS and control was examined with latex enhanced immunoturbidimetry. Results: The levels of sIL-6R and sgp130 were significantly elevated in TS compared with control group (44.1 15.8 vs 30.3 9.0, P<0.01；69.0 24.6 vs 47.3 14.1，P<0.01, respectively) . ASO titer ( 250IU/ml) were found higher in TS than that in control（P 0.01）. The positive rates of anti-brain antibody and antinuclear antibody in TS were higher than that in control group as well (66% vs 4% p 0.01; 53% vs 25%, p 0.01). The level of ABAb negatively correlated with sgp130 concentration (r= 0.375, p<0.05). Conclusion: IL-6 signal transduction might be involved in Tourette's syndrome to lead the function upward and start the network mechanism of feedback inhibition, because elevated levels of sIL-6R, sgp130，ANAb and ABAb in serum. Autoimmune-related injuries may participate in the pathogenesis of the disease.

Key words: Tourette’s Syndrome, Autoantibodies, anti-streptolysin O, sIL-6R, sgp130