基础医学与临床 ›› 2010, Vol. 30 ›› Issue (1): 97-99.

• 短篇综述 • 上一篇    下一篇

结直肠癌个体化治疗的研究进展

李进 何敬东   

  1. 南京医科大学附属淮安医院
  • 收稿日期:2009-06-22 修回日期:2009-08-27 出版日期:2010-01-05 发布日期:2010-01-05
  • 通讯作者: 李进

Progress on individual therapy of colorectal cancer research

Jin LI, Jing-dong HE   

  1. HuaiAn Hospital Affiliated Nanjing Medical University
  • Received:2009-06-22 Revised:2009-08-27 Online:2010-01-05 Published:2010-01-05
  • Contact: Jin LI,

摘要: 化疗在晚期大肠癌的治疗中具有重要地位。不同化疗药物的选择影响疗效和预后。以药物基因组学为基础的大肠癌个体化治疗开始得到重视,本文就分子标记对大肠癌化疗药物包括氟脲嘧啶类、奥沙利铂、伊立替康及分子靶向药物疗效影响的研究现状进行综述,探讨大肠癌个体化治疗发展。

关键词: 分子标记, 结直肠癌, 化疗

Abstract: Chemotherapy plays an important role in advanced colorectal cancer.patient may acquire various clinical response by selection different drugs .the importance of individual therapy which based on Pharmacogenomics has been emphasized in cancer therapy. To explore the individual therapy of colorectal cancer ,the progress of molecular markers which influence the efficacy of anti-tumor drugs containing Fluorouracil,Oxaliplatin,CPT-11, Monoclonal antibody drugs is reviewed in this article.