关键词: 大肠癌, 转移相关因子, 核因子κB, 进展和转移

Abstract: Objective To investigate the relationship between NF-κB activation and the expression of metastasis correlation factors. Methods The expression of NF-κB，COX-2, ICAM-1, VCAM-1 and MMP-9 in cancer and normal tissues was detected using Western blotting. Results 1. The expression level of NF-κB was higher in cancer tissues than that in normal tissues (P<0.05). 2. The expression of COX-2, ICAM-1 and VCAM-1 was higher in 75% cancer tissues, in which NF-κB was high expression. 3. MMP-9 expression was negatively correlated with its profilin SM22α. Conclusion The expression of metastasis correlation factors was positively related with the activation of NF-κB, and was responsible for the progression of colorectal carcinoma and poor prognosis.

Key words: colorectal carcinoma, metastasis correlation factors, NF-κB, progression and metastasis