基础医学与临床 ›› 2009, Vol. 29 ›› Issue (3): 273-276.

• 研究论文 • 上一篇    下一篇

骨髓间质干细胞移植治疗兔缺血性心脏病

马国涛 任华 朱朝晖 张超纪   

  1. 中国医学科学院 北京协和医学院, 北京协和医院心脏外科 中国医学科学院 北京协和医学院, 北京协和医院心脏外科 中国医学科学院 北京协和医学院, 北京协和医院心脏外科 中国医学科学院 北京协和医学院, 北京协和医院心脏外科
  • 收稿日期:2008-05-20 修回日期:2008-07-28 出版日期:2009-03-25 发布日期:2009-03-25
  • 通讯作者: 马国涛

Marrow mesenchymal stem cells transplantation for ischemic heart disease in rabbits

Guo-tao MA, Hua REN, Zhao-hui ZHU, Chao-ji ZHANG   

  1. Department of Cardiac Surgery, PUMC Hospital, CAMS &PUMC Department of Cardiac Surgery, PUMC Hospital, CAMS &PUMC Department of Cardiac Surgery, PUMC Hospital, CAMS &PUMC Department of Cardiac Surgery, PUMC Hospital, CAMS &PUMC
  • Received:2008-05-20 Revised:2008-07-28 Online:2009-03-25 Published:2009-03-25
  • Contact: Guo-tao MA,

摘要: 目的 探讨骨髓间质干细胞移植治疗缺血性心脏病的可行性。方法 由新西兰大白兔胸骨获取骨髓间充质干细胞并进行培养。结扎前降支,建立兔心肌梗死模型。将骨髓间质干细胞分别移植于心肌梗死区,用PET检查梗死区面积,监测左心室内压最大上升速度dp/dt来判定心功能。结果 细胞移植后心肌梗死区面积较移植前缩小,心功能较移植前明显改善。结论 移植骨髓间质干细胞能改善实验动物的心功能。

Abstract: Objective To investigate the feasibility of treating ischemic heart disease with transplantation of marrow mesenchymal stem cells. Methods Marrow mesenchymal stem cells were taken from New Zealand rabbit's sternum and cultured. A myocardial infarction model was created by ligation of the distal left anterior descending artery in New Zealand rabbit. MSCs were injected into the region of myocardial infarction. The size of the myocardial infarction area was measured by PET and the cardiac function was assessed by measuring the pressure change of left ventricle(dp/dt). Results The size of the myocardial infarction area diminished and the cardiac function of the New Zealand rabbit was improved after the transplantation of marrow mesenchymal stem cells. Conclusion Transplantation marrow mesenchymal stem cells may improve cardiac function of ischemic heart disease in New Zealand rabbit.