基础医学与临床 ›› 2009, Vol. 29 ›› Issue (2): 212-215.

• 短篇综述 • 上一篇    下一篇

脑钠素与心血管疾病

周小艳 韩金祥 高雪芹 朱波   

  1. 山东省医药生物技术研究中心 山东省医药生物技术研究中心 山东省医药生物技术研究中心
  • 收稿日期:2007-10-30 修回日期:2008-05-22 出版日期:2009-02-25 发布日期:2009-02-25
  • 通讯作者: 周小艳

BNP and Cardiovascular Events

Xiao-yan ZHOU, Jin-xiang HAN, Xue-qin GAO, Bo ZHU   

  1. Shandong Medicinal and Biotechnological Center Shandong Medicinal and Biotechnological Center Shandong Medicinal and Biotechnological Center
  • Received:2007-10-30 Revised:2008-05-22 Online:2009-02-25 Published:2009-02-25
  • Contact: Xiao-yan ZHOU,

摘要: 脑钠素(B-type natriuretic peptide,BNP)是1988年发现的,是心脏分泌的一种激素,它属于利钠多肽家族的一种。与其它利钠多肽成员相同,对交感神经、肾素-血管紧缩素-醛固酮系统有抑制作用。BNP与心血管疾病的关系一直是研究的焦点.目前,临床上,可以通过检测BNP水平诊断呼吸困难的病人是肺源性还是心源性的。BNP对心血管疾病的诊断、治疗、预后的作用正在进一步研究中。现对脑钠素的分子生物学研究及在心血管疾病中的作用研究进展作一综述。

关键词: 脑钠素, 分子生物学, 心血管疾病

Abstract: B-type natriuretic peptide,a heart-derived hormone, was found in 1988, which belongs to natriuretic peptides.Like other natriuretic peptides, it can also inhibit the renin-angiotensin-aldosterone system and sympathetic system,and conclusively, play a crucial role in cardiovascular homeostasis. The relationship between BNP and cardiovascular events has always been an issue. So far, clinically, BNP testing has been useful in the evaluation of heart failure as a cause of acute dyspnea in the emergency department. The role of BNP in cardiovascular events diagnosis, therapy and prognosis still calls for further investigation. In this narrative review, we will summarize the progressive investigation of BNP molecular biology and its role in cardiovascular events

Key words: BNP, Molecular Biology, Cardiovascular Events