BID蛋白促细胞凋亡增殖失衡作用与IgA肾病患者病情的关系

基础医学与临床 ›› 2009, Vol. 29 ›› Issue (2): 166-169.

BID蛋白促细胞凋亡增殖失衡作用与IgA肾病患者病情的关系

马琳傅淑霞杨林王建荣

河北医科大学第二医院肾内科河北医科大学第二医院肾内科河北医科大学第二医院肾内科河北医科大学第二医院肾内科

收稿日期:2007-08-13 修回日期:2008-05-04 出版日期:2009-02-25 发布日期:2009-02-25
通讯作者: 傅淑霞

Relation between the role of promoting disequilibrium of cell proliferation and apoptosis of BID and the pathogenetic condition of IgAN

Lin MA, Shu-xia FU, Lin YANG, Jian-rong WANG

Department of Nephrology,The Second Hospital of Hebei Medical University Department of Nephrology,The Second Hospital of Hebei Medical University Department of Nephrology,The Second Hospital of Hebei Medical University Department of Nephrology,The Second Hospital of Hebei Medical University

Received:2007-08-13 Revised:2008-05-04 Online:2009-02-25 Published:2009-02-25
Contact: Shu-xia FU,

摘要/Abstract

摘要： 目的探讨IgA肾病(IgAN)不同病变程度肾组织中BID蛋白的表达与细胞凋亡、增殖的关系。方法免疫组化法检测肾组织PCNA、BID蛋白和FN,用原位末端标记法(TUNEL)结合光镜形态学检测细胞凋亡情况。结果随IgAN病变程度加重，BID蛋白、PCNA、凋亡细胞及FN表达逐渐增强(P<0.05), Ⅳ级最强 (PCNA：Ⅲ、Ⅳ相当)；肾小球内BID蛋白与凋亡细胞比值、PCNA 、FN表达,肾小球硬化率及尿蛋白排泄量正相关，与eGFR负相关(Ｐ均<0.01)。结论 BID蛋白可通过促进细胞凋亡增殖失平衡促进IgAN病程进展，可能为判断预后的一项重要病理指标。

关键词: BID蛋白, 细胞凋亡, TUNEL, PCNA, FN, IgA肾病

Abstract: Objective:To explore the expression of BID and the relation between cell proliferation and apoptosis at various stages of IgAN. Method:The expression of BID、PCNA and FN in renal tissue were detected by immunohistochemistry, TUNEL and light microscope were used to detect apoptotic cells. Result:With the progress of IgAN, the expression of BID、PCNA、the number of apoptotic cells and FN increased gradually (P< 0.05),especially in IV group(PCNA：Ⅳ is in the same rank as Ⅲgroup), The expression of BID in glomcrulus had positive correlation with the rate of apoptotic cells、the express of PCNA and FN、the rate of glomerular sclerosis and urine protein，and had negative correlation with glomerular filtration rate(P<0.01).Conclusion: BID can accelerate the progression of IgAN through promoting disequilibrium of cell proliferation and apoptosis，and it may serve as a marker for judging prognosis.

Key words: BID Protein, apoptosis, TUNEL, PCNA, FN, IgAN

马琳傅淑霞杨林王建荣. BID蛋白促细胞凋亡增殖失衡作用与IgA肾病患者病情的关系[J]. 基础医学与临床, 2009, 29(2): 166-169.

Lin MA; Shu-xia FU; Lin YANG; Jian-rong WANG. Relation between the role of promoting disequilibrium of cell proliferation and apoptosis of BID and the pathogenetic condition of IgAN[J]. Basic & Clinical Medicine, 2009, 29(2): 166-169.

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