基础医学与临床 ›› 2009, Vol. 29 ›› Issue (11): 1194-1197.

• 研究论文 • 上一篇    下一篇

遵义地区人群激素敏感脂肪酶基因i6多态性分布

葛斌 路健 李学英   

  1. 遵义医学院附属医院生殖中心 遵义医学院细胞生物学与遗传学教研室
  • 收稿日期:2008-12-05 修回日期:2009-02-18 出版日期:2009-11-20 发布日期:2009-11-20

Distribution of the hsl gene i6 Polymorphism in the ZunYi Region

Bin GE, Jian LU, Xue-ying LI   

  1. Center for Reproductive of the Affiliated Hospital, Zunyi Medical College Department of Cell Biology and Genetics, Zunyi Medical College
  • Received:2008-12-05 Revised:2009-02-18 Online:2009-11-20 Published:2009-11-20

摘要: 目的 探讨遵义地区人群hsli6多态性分布情况。方法 采用聚合酶链式反应-单链构象多态性分析(PCR-SSCP)方法,检测247例中国遵义地区人群hsli6多态性,并分析其在人群中的分布情况。结果 hsli6检测出6种等位基因片段,11种基因型。其多态信息含量大于0.7。其中等位基因6、7基因频率分布最广。结论 hsli6在遵义地区人群中具有多态分布,为hsl作为糖脂代谢研究候选基因提供了相关依据。

关键词: 激素敏感性脂肪酶, 基因多态性分布

Abstract: Objective Explore the polymorphism distribution of the hormone-sensitive lipase (HSL) gene i6 in ZunYi region. Methods Examine the polymorphism of the hsl i6 in the ZunYi population with ploymerase chain reaction- single strand conformation polymorphism (PCR-SSCP), and. analyzing the distribution of it. Results 6 different alleles and 11 different genotypes were found in the hsl i6. The PIC is more than 0.7, in which allele 6 and allele 7 have the most widely distributed Conclusion The polymorphism of hsl i6 was distributed in ZunYi.. And it provides the relevant for hsl as a candidate gene of glucose and lipid metabolism.

Key words: hormone-sensitive lipase, gene polymorphism distribution

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