关键词: 宫颈癌, 人乳头瘤病毒, 人类组织相容性抗原, SBT

Abstract: Objective To study the relationship between HLA-A alleles, supertype, HPV infection and cervical cancer in Tu Nationality of Hubei province.Methods in the same geographic region and of similar age .The comparisons included the comparison between HPV positive cases and HPV positive women in control group, and the comparison between HPV positive cases and HPV negative women in control group. Number of cases was 100( HPV positive was 86) , and control was 187 (HPV positive was 95 and HPV negative was 92). The most polymorphism of 2 and 3 exons of the HLA-A alleles were analyzed by the high-resolution typing method-sequence-based typing(SBT). Results Comparison between HPV positive cases and HPV positive control women. Supertype HLA-A3 (pcorrected=0.005, OR=2.36, 95％CI＝1.45-3.85) was risk factors. Comparison between HPV positive cases and HPV negative control women, HLA-A*0206 alleles（pcorrected=0.025 ,OR=0.20，95％CI＝0.07-0.58）Supertype HLA-A2(pcorrected=0.005, OR=0.57，95％CI＝0.37-0.88）was protective factor. SupertypeHLA-A3 （pcorrected=0.005, OR=2.36, 95％CI＝1.45-3.85) was also related to the susceptibility of cervical carcinoma.Concusion SupertypeHLA-A3 was risk factor of cervical cancer.

Key words: Cervical cancer, Human papillomavirus (HPV), Human leukocyte antigen (HLA), SBT