基础医学与临床 ›› 2008, Vol. 28 ›› Issue (9): 940-943.

• 研究论文 • 上一篇    下一篇

脂联素基因+45位T/G多态性与2型糖尿病遗传易感性的相关性

魏颖丽 何兰杰 霍正浩 赵巍   

  1. 浙江武警总队医院杭州医院 宁夏医学院附属医院内分泌科 宁夏医学院 宁夏医学院医学遗传学与细胞生物学教研室
  • 收稿日期:2006-04-05 修回日期:2008-01-30 出版日期:2008-09-25 发布日期:2008-09-25
  • 通讯作者: 霍正浩

SNP 45(T/G) of adiponectin gene polymorphism and genetic susceptibility to type 2 diabetes mellitus

Ying-li WEI, Lan-jie HE, Zheng-hao HUO, Wei ZHAO   

  1. Zhejiang Provincial Crops Hospital, Chinese People's Armed Police Forces Ningxia Medical College
  • Received:2006-04-05 Revised:2008-01-30 Online:2008-09-25 Published:2008-09-25
  • Contact: Zheng-hao HUO,

摘要: 目的:研究脂联素基因单核苷酸多态性(SNP)45(T/G)位点与宁夏汉族人群2型糖尿病之间的关系。方法:选择100例2型糖尿病患者和101例正常对照者,采用聚合酶链式反应一限制性内切酶长度多态性(PCR-RFLP)技术,对脂联素基因SNP45多态性位点进行基因分型同时测定代谢参数。结果:2型糖尿病组SNP45位点GG基因型频率和G等位基因频率均高于正常对照组(分别为13% vs 3%;76% vs 24%,均P<0.05)。结论:脂联素基因的SNP45多态性位点与宁夏汉族人群中2型糖尿病相关,GG基因型者具有2型糖尿病高易感性。

Abstract: Objective To investigate the association of single nucleotide polymorphisms (SNP)45T/G in the adiponectin gene with type 2 diabetes of Han nationality in Ningxia.. Methods PCR- RFLP method was used to determine the distributions of alleles and genotypes frequencies of SNP45T/G polymorphisms in adiponectin gene in 100 type 2 diabetic patients and 101 normal subjects .Results The distribution of both genotypes and alleles frequencies of the SNP45 polymorphisms were significantly different between two groups(GG genotype:13% vs 3% ,P<0.05;G allele;76% vs 24%, P<0.05). Conclusion The results suggest that SNP45 in adiponectin gene was associated with type 2 diabetes of Han nationality in Ningxia. Individuals with SNP45 GG genotypes of adiponectin gene have high susceptibility to type 2 diabetes.