Abstract: Objective To improve the understanding of pelvic lipomatosis. Methods The clinical features of eight patients (all males, aged 26-64years) with pelvic lipomatosis who were admitted to Peking Union Medical College Hospital from 1983 to November 2006 and the clinical and pathologic features, treatment and prognosis were analyzed. The course of disease before admission was（95±82）months, The time of follow-up was（15±32）months, five cases performed upper tract urinary diversion, one case performed urinary tract diversion and received steroids, one case received steroids treatment. Result Four cases had cystitis glandularis, Frequency and urgency of micturition were observed in three cases. Dysuria in three cases, hematuria in three cases, and hypertension in five cases were present during the course of disease. Renal insufficiency was observed all of eight cases (Mean Ccr were 76±18ml/min). All cases had abnormal features in their image investigation, which indicated excessive pelvic fat directly or indirectly. Six cases had upper tract distention. Four cases underwent pelvic tissue biopsy. The result of biopsy was fat-vessel tissue. Their symptoms，not renal function, were relieved after treatment。Conclusion The symptoms of pelvic lipomatosis are atypical, they had renal insufficiency, and their diagnosis mainly depends on image investigation and pathologic examination.