Abstract: Objective To observe the effects of global ischemia-reperfusion on inhibitory synaptic function in hippocampal CAl region of adult rats. Methods All animals were randomly divided into three groups: sham-operation group (SH), ischemia-reperfusion 3 day (IR-3) and 7 day group (IR-7). Global ischemic episode was achieved by 4-vessel occlusion．Evoked inhibitory postsynaptic currents (eIPSCs) were recorded from CA1 pyramidal cells in hippocampal slices using whole-cell voltage-clamp. Results The eIPSCs amplitudes generated by lower stimulus intensities were significantly (p <0.05) decreased in both IR-3 and IR-7 rats compared with SH rats. Moreover, the rise time of eIPSCs in IR-7 group was significantly decreased compared with SH group (p <0.05)，but the paired pulse depression of eIPSCs was significantly increased in IR-3 group compared with SH rats. Conclusion Ischemia-reperfusion injury decreased GABA-mediated synaptic function in the hippocampal CA1 region of adult rats.