基础医学与临床 ›› 2008, Vol. 28 ›› Issue (11): 1219-1222.

• 短篇综述 • 上一篇    下一篇

基质信号蛋白CCN1心血管作用研究进展

喻杨 黄岚   

  1. 第三军医大学 新桥医院 全军心血管内科研究所 第三军医大学 新桥医院 全军心血管内科研究所
  • 收稿日期:2007-11-22 修回日期:2008-01-04 出版日期:2008-11-25 发布日期:2008-11-25
  • 通讯作者: 喻杨

Progress in the effects of CCN1 on cardiovascular system

Yang YU, Lan HUANG   

  1. Institute of Cardiology, Xingqiao Hospital, TMMU Institute of Cardiology, Xingqiao Hospital, TMMU
  • Received:2007-11-22 Revised:2008-01-04 Online:2008-11-25 Published:2008-11-25
  • Contact: Yang YU,

摘要: 基质信号蛋白CCN1由381个氨基酸残基构成的4个独立结构模块,富含38个保守半胱氨酸,在心血管系统具有广泛的生物学活性,影响血管内皮细胞、平滑肌细胞以及心肌细胞的分化、增殖和迁移;在血管生成、血管损伤修复、心脏发育、心肌梗死等多种病理生理过程中起重要作用。

关键词: CYR61, CCN1, 心血管

Abstract: CCN1 is a novel extracellular matrix-associated signaling protein which possesses 381 amino-acid residues to compose 4 distinct structural modules with 38 conserved cysteine residues.This protein has a variety of properties in cardiovascular system, affecting the cellular behaviors such as differentiation, proliferation and migration of vascular endothelial cells, smooth muscle cells and cardiac myocytes, suggesting an essential roles of CCN1 in angiogensis, vascular injury, cardiac development and myocardial infarction.

Key words: CYR61, CCN1, cardiovascular