基础医学与临床 ›› 2008, Vol. 28 ›› Issue (10): 1107-1110.

• 短篇综述 • 上一篇    下一篇

癌蛋白质组学技术及其应用

魏晓丽 王悦   

  1. 南开大学医学院 南开大学医学院
  • 收稿日期:2007-12-14 修回日期:2008-01-31 出版日期:2008-10-25 发布日期:2008-10-25
  • 通讯作者: 王悦

Oncoproteomics and its application

Xiao-li WEI, Yue WANG   

  • Received:2007-12-14 Revised:2008-01-31 Online:2008-10-25 Published:2008-10-25
  • Contact: Yue WANG

摘要: 蛋白质组学的研究由二维电泳的引进揭开序幕,而近年来质谱技术和蛋白质芯片的广泛引入使得蛋白质组学技术得到越来越多的应用,尤其是应用在肿瘤研究中。癌蛋白质组学以整个肿瘤特异性蛋白信号网络为靶标,已应用到多种癌症的研究中,成为肿瘤研究的重要工具。本文将对癌蛋白质组学技术原理以及其近年来在肿瘤研究中的应用加以综述。

关键词: 癌蛋白质组学二维电泳质谱技术蛋白质芯片

Abstract: Proteomic research first came to the fore with the introduction of two-dimensional gel electrophoresis and proteomics has been increasingly applied to cancer research with the wide-spread introduction of mass spectrometry and protein chip. As important research tools, oncoproteomics that targets the entire cancer-specific protein network has already been applied in cancer research .In this article the development of the oncoproteomics and its applying in cancer is reviewed.

Key words: Oncoproteomics two dimensional electrophoresis mass spectrometry protein chip