甲状腺过氧化物酶抗体在甲亢、甲状腺占位性病变诊治中的临床意义

基础医学与临床 ›› 2007, Vol. 27 ›› Issue (7): 819-821.

甲状腺过氧化物酶抗体在甲亢、甲状腺占位性病变诊治中的临床意义

张玉国王玉农

河北省张家口市第一医院外三科河北省张家口市第一医院外三科

收稿日期:2006-08-28 修回日期:2006-10-08 出版日期:2007-07-25 发布日期:2007-07-25
通讯作者: 王玉农

Clinical significance of Thyroid Peroxidase Antibody Level in the Diagnosis and Treatment of Hyperthyroidism and Thyroid gland tumor

Received:2006-08-28 Revised:2006-10-08 Online:2007-07-25 Published:2007-07-25

摘要/Abstract

摘要： 目的：观察不同临床治疗阶段甲亢、甲状腺占位性病变患者血清甲状腺过氧化物酶抗体(TPOAb)浓度的变化，探讨其临床指导价值。方法：采用固相化学发光酶免疫分析法观察血清 TPOAb浓度变化与甲状腺功能减退（化验室检查结果）的关系。结果： 89例病人中，有50例病人治疗前TPOAb正常或仅轻度增高，治疗后呈现阳性者31例，其中19例发生了甲减或亚临床型；39例治疗前TPOAb阳性，治疗后转阴2例，26例浓度降低，发生甲减3例，29例病人服用不同剂量的甲状腺片而未出现甲减或亚临床型。结论：甲亢和甲状腺占位性病变患者在治疗过程可伴有 TPOAb浓度的变化，TPOAb 的明显增高，预示出现甲减的可能性大，TPOAb阳性的病人应被关注，高滴度TPOAb的甲亢病人治疗方案的选择要慎重。

关键词: 甲亢, 甲状腺占位性病变, 甲状腺过氧化物酶抗体, 甲状腺功能减退

Abstract: Objective: to observe the changes of serum thyroid peroxidase antibody (TPOAb) in the patients with Hyperthyroidism and Thyroid gland tumor in different phases. Methods: the levels of TPOAb were observed, the relation between the changed TPOAb level and reduced thyroid function was studied. Results: Amount 89 cases, there were 50 cases having normal or slightly elevated TPOAb level. However, after treatment, 31 cases presented a raised TPOAb level. Of 19 cases with hypothyroidism or its sub-clinical type. There were 39 cases with positive TPOAb. After the treatment, 2 cases changed to negative TPOAb, 26 cases lowered, and 3 cases had hypothyroidism. There were 29 cases taking thyroid tablets without appearance of hypothyroidism. Conclusion: the changes of TPOAb level can be observed during the treatment for hyperthyroidism and t hyroid gland tumor. The elevated TPOAb level often predicts the decreased thyroid function. The patients with positive TPOAb should be concerned, and for hyperthyroidism patients the treatment should be taken with care.

Key words: hyperthyroidism, thyroid gland tumor, thyroid peroxidase antibody, hypothyroidism

张玉国王玉农. 甲状腺过氧化物酶抗体在甲亢、甲状腺占位性病变诊治中的临床意义[J]. 基础医学与临床, 2007, 27(7): 819-821.

. Clinical significance of Thyroid Peroxidase Antibody Level in the Diagnosis and Treatment of Hyperthyroidism and Thyroid gland tumor[J]. Basic & Clinical Medicine, 2007, 27(7): 819-821.