Abstract: Hepatitis B virus infection can result in different clinical outcomes which consist of self-limited infection（virus clearance）, inactive carrier status, chronic hepatitis B and cirrhosis. The mechanism led to individual discrepancy for outcome of hepatitis B virus infection is unknown at present. It is suspected that the outcomes of hepatitis B virus infection might be associated with the inherent factors of host. It is summarized that the results of association studies between genetic polymorphisms of HLA-I, II class, TNF-α and VDR and different clinical outcome of hepatitis B virus infection in recent years in this review.