男性性早熟临床特点分析

基础医学与临床 ›› 2007, Vol. 27 ›› Issue (5): 580-583.

男性性早熟临床特点分析

伍学焱茅江峰李乃适朱惠娟顾锋陆召麟史自孟史轶蘩

北京协和医院内分泌科协和医院内分泌科协和医院内分泌科协和医院内分泌科

收稿日期:2006-10-13 修回日期:2006-12-04 出版日期:2007-05-25 发布日期:2007-05-25
通讯作者: 伍学焱

Clinical Characteristics of Precocity in Boys

Received:2006-10-13 Revised:2006-12-04 Online:2007-05-25 Published:2007-05-25

摘要/Abstract

摘要： 目的探讨男性性早熟的临床特点。方法回顾性分析26例男性性早熟患儿的病因诊断、治疗和预后；比较生殖细胞瘤、下丘脑错构瘤和先天性肾上腺皮质增生症（CAH）3组不同病因引起的男性性早熟在临床特点和激素水平方面的差异。结果 26例男性性早熟中，CAH8例，生殖细胞瘤7例，下丘脑错构瘤5例，特发性性早熟3例，肾上腺腺瘤2例，脑膜脑炎后遗症1例。通过分析，血清黄体生成素（LH）、卵泡刺激素（FSH）、睾酮（T）等性激素水平、睾丸体积和病程长短等，结果显示3组之间有显著差异（P<0.05）。结论本组男性性早熟的主要病因是CAH、颅内生殖细胞瘤和下丘脑错构瘤。及早明确诊断对治疗和预后至关重要。

Abstract: Objective To investigate the clinical characteristics of precocity in boys. Methods Retrospectively analysis of 26 cases with precocity in boys in Peking Union Medical College Hospital from 1988 to 2005. Congenital adrenal hyperplasia (CAH), germinoma and hypothalamic hamartoma are the main causes of precocity. Clinical characteristics and hormone levels were compared among three groups. Results In 26 cases, 8 were CAH, 7 were germinoma, 5 were hypothalamic hamartoma, 3 were idiopathic precocity, 2 were adrenal adenoma, 1 was due to the complication with encephalitis. The levels of serum luteinizing hormone(LH)，follicular stimulating hormone(FSH)，total testosterone(T)，testis volume，and duration of manifestation between three groups were significantly different. Conclusion CAH, germinoma and hypothalamic hamartoma were the main causes of precocity in boys. Early diagnose is essentially important for further treatment and prognosis.

伍学焱茅江峰李乃适朱惠娟顾锋陆召麟史自孟史轶蘩. 男性性早熟临床特点分析[J]. 基础医学与临床, 2007, 27(5): 580-583.

. Clinical Characteristics of Precocity in Boys[J]. Basic & Clinical Medicine, 2007, 27(5): 580-583.