基础医学与临床 ›› 2007, Vol. 27 ›› Issue (5): 561-564.

• 研究论文 • 上一篇    下一篇

内脏高敏感大鼠结肠电活动及运动异常

印媛君 吕宾 杨午鸣 柯庆 丁瑞峰   

  1. 浙江中医药大学基础医学院生理教研室 浙江中医药大学基础医学院生理教研室 浙江中医药大学基础医学院生理教研室 浙江中医药大学基础医学院生理教研室
  • 收稿日期:2006-08-29 修回日期:2006-12-11 出版日期:2007-05-25 发布日期:2007-05-25
  • 通讯作者: 丁瑞峰

Ubnormal colonic electricity activity and motion of visceral hypersensitivity rat

  

  • Received:2006-08-29 Revised:2006-12-11 Online:2007-05-25 Published:2007-05-25

摘要: 目的 探讨内脏高敏感大鼠结肠电活动及运动的特点。方法 实验分对照组和模型组,模型组腹腔注射鸡卵清蛋白使大鼠内脏致敏。2周后,记录结肠快波、慢波及收缩波,观察消化间期移行性综合肌电IMC的周期、III期持续时间、快波和慢波的波动频率及平均最大振幅,记录结肠收缩波数目及收缩波指数。结果 模型组消化间期复合肌电的周期延长(P<0.01),III期持续时间延长(P<0.01),快波的波动率加快(P<0.05),平均最大振幅增大(P<0.01)。慢波的波动频率加快(P<0.05),平均最大振幅增大(P<0.01)。收缩波数目增加(P<0.05),收缩波指数增大(P<0.05)。结论 内脏高敏感大鼠结肠电活动及运动有明显异常。

Abstract: Objective The features was probed into by colonic electricity and motion in visceral hypersensitivity rat. Methods The experiment consists of the control series and the model series ,and the latter series were sensitized by intraperitoneal injection of chicken egg albumen.After two weeks, the colon spike potential 、slow wave and the colon contraction were written and the interdigestive myoelectric complex cycle,III phase times, spike potential and slow wave propagation rate、the average largesttest amplitude were observed,and the number of the contraction 、the index of contraction were noted. Result The IMC cycle and III phase times of model group prolongs (P<0.01),and spike potential propagation rate speeds up (p<0.05),and the largesttest amplitude increases (P<0.01).The slow wave propagation rate speeds up (p<0.05) and the largesttest amplitude increases(P<0.01). The number of the contraction increases (p<0.05)and the index of contraction grows(p<0.05). Conclusion There are quite difference between model group and control group in electricity and motion of visceral hypersensitivity rat.