Abstract: Objective To investigate the relationship between expression of survivin and CD44v6 and HPV16/18 infection in uterine cervical carcinogenesis. Methods Using Streptavidin-Peroxidase(S-P) immunohistochemical technique, the authors examined the expression of survivin and CD44v6 in samples. The infection of HPV type 16,18 DNA were determined by PCR. Results There were significant differences for survivin and CD44v6 between carcinomas, CIN and normal cervices（P<0.01,respectively）. Expression of CD44v6 was correlated with tumor grades, clinical stages and lymph node metastasis（P<0.05）, and expression of survivin was associated with tumor grades and lymph node metastasis（P<0.05）. The positive rate of HPV16/18 was significant difference between cervical carcinomas, CIN and normal tissues（P<0.01）and was not associated with tumor grades, clinical stages and lymph node metastasis. The infection of HPV16/18 was associated with the expression of survivin（P<0.05）. Conclusions The abnormal expression of survivin is associated with the infection of HPV16/18. survivin and CD44v6 possibly become useful indexes for the primary screening and prognosis of cervical carcinomas.