低强度超声对兔激素性高眼压影响的实验研究

基础医学与临床 ›› 2007, Vol. 27 ›› Issue (3): 284-287.

低强度超声对兔激素性高眼压影响的实验研究

陈琳（川）刘苏

重庆医科大学第二医院眼科重庆重庆医科大学附属第二医院

收稿日期:2005-06-01 修回日期:2006-04-17 出版日期:2007-03-25 发布日期:2007-03-25
通讯作者: 陈琳（川）

Effect of low intensive ultrasound on dexamethasone-induced intraocular hypertension in rabbit

Received:2005-06-01 Revised:2006-04-17 Online:2007-03-25 Published:2007-03-25

摘要/Abstract

摘要： 目的探讨低强度超声对兔激素性高眼压的影响及其机制。方法采用超声直接接触法对兔激素性高眼压连续治疗5d并监测眼压。观察眼压、小梁组织的HE染色，透射电镜、免疫组化法及图像分析观察小梁外基质层黏连蛋白、纤维连接蛋白和胶原Ⅰ的变化。结果低强度超声处理后眼压有显著下降，小梁网间隙增大，胶原I、层黏连蛋白及纤维连接蛋白的表达低于对照组。结论低强度超声所致眼压降低与小梁组织超微结构改变及超声机械震荡等使异常增多的小梁外基质减少有关。

Abstract: Objective To investigate the effect of low-intensity ultrasound on intraocular hypertension and its mechanicsm． Methods　 The intraocular hypertension rabbits were treated with ultrasound .The intraocular pressure(IOP), trabecular meshwork HE staining ,transmission electron microscope, extracellular matrix through immunohistochemistry were observed．　Results　After treatment, IOP was descended and trabecula interspace was wider than the control eye. The expression of collagen I,laminin and fibronectin was lower than control group. Conclusion　Low-intensity ultrasound can decrease IOP. It maybe relate with the change of trabecular meshwork histologic structure .

陈琳（川）刘苏. 低强度超声对兔激素性高眼压影响的实验研究[J]. 基础医学与临床, 2007, 27(3): 284-287.

. Effect of low intensive ultrasound on dexamethasone-induced intraocular hypertension in rabbit[J]. Basic & Clinical Medicine, 2007, 27(3): 284-287.