Abstract: Objective To review the diagnosis and therapy of adrenal myelolipoma (ML). Methods The medical records of 21 patients with adrenal myelolipoma were reviewed. All patients were examined by B-ultrasound, CT and endocrine tests while some were examined by MRI and 131I-MIBG in addition. Results All patients had undergone resection of adrenal ML. The mean diameter of tumors was 6.7cm (4.5cm~12cm). Pathological examination of all tumors confirmed the diagnosis of adrenal ML. No recurrence was observed during the follow-up period (1~15years).Conclusion Adrenal ML is a rare, benign tumor and is often discovered incidentally. Its prognosis is generally good.