基础医学与临床 ›› 2007, Vol. 27 ›› Issue (12): 1388-1391.

• 临床园地 • 上一篇    下一篇

自体外周血干细胞移植促进患者下肢动脉缺血性溃疡愈合

师天雄 缪建航 孙健鸣 胡锡祥 张明光   

  1. 广东中山市人民医院 广东中山市人民医院 广东中山市人民医院 广东中山市人民医院 广东中山市人民医院
  • 收稿日期:2007-06-27 修回日期:2007-09-24 出版日期:2007-12-25 发布日期:2007-12-25
  • 通讯作者: 师天雄

Transplantation of autologous peripheral blood stem cells accelerates ulcer cicatrisation in ischemic disease of lower limb arterial

Tian-xiong SHI, Jian-hang MIAO, Jian-ming SUN, Xi-xiang HU, Ming-guang ZHANG   

  1. Department of General Surgery, Zhongshan people's hospital
  • Received:2007-06-27 Revised:2007-09-24 Online:2007-12-25 Published:2007-12-25
  • Contact: Tian-xiong SHI,

摘要: 目的 探讨应用自体外周血干细胞移植技术治疗患者下肢动脉缺血性溃疡和静息痛可行性及存在的问题。方法 自2004年3月到2007年2月,16例下肢动脉缺血性溃疡及静息痛患者通过采用重组人粒细胞集落刺激因子(G-CSF)动员骨髓干细胞增殖并释放入血,在第5~6天应用血细胞分离机进行外周血干细胞的采集,并将采集到的浓集干细胞液作患肢小腿肌肉注射。结果 16例患者经干细胞移植治疗后间歇性跛行时间及距离均延长,其中,12例患者静息痛均缓解;11例溃疡愈合。病人均随访3~24个月。4例失访。结论 应用自体外周血干细胞移植技术治疗下肢动脉缺血性溃疡和静息痛是一种可行且有疗的方法。

Abstract: Objective To evaluate the clinical efficacy of transplantation of autologous peripheral blood stem cells (PBSC) for the treatment of toe or heel ulcer and rest pain in lower limb arterial ischemic diseases. Methods Mobilized patients' own stem cells with G-CSF for 5 days. On the sixth day, PBSC were collected with a blood-cells separator. Later, the PBSC were intramuscularly injected into the ischemic areas of the lower limbs. Results After transplantation, all patients were followed up from 3 to 24 months. The rest pain disappeared in 12 patients,while toe or heel ulcers were cicatrized in 11 cases. However, 4 patients lost. Conclusion Transplantation of autologous peripheral blood stem cells is an effective method for arterial ischemic disease.