HOXA11在子宫内膜单纯性增生和内膜癌中表达增加

基础医学与临床 ›› 2007, Vol. 27 ›› Issue (10): 1123-1126.

HOXA11在子宫内膜单纯性增生和内膜癌中表达增加

胡营营唐颖王莉芬吕丽王乃玉冯晓海堂远馨

大连医科大学附属第二医院病理科大连医科大学附属第二医院病理科大连医科大学附属第二医院病理科大连医科大学附属第二医院病理科大连医科大学附属第二医院病理科大连医科大学附属第二医院病理科四川省广汉市人民医院病理科

收稿日期:2006-09-19 修回日期:2007-02-26 出版日期:2007-10-25 发布日期:2007-10-25
通讯作者: 胡营营

Expression of HOXA 11 in human endometrial hyperplasia and adenocarcinoma

Received:2006-09-19 Revised:2007-02-26 Online:2007-10-25 Published:2007-10-25

摘要/Abstract

摘要： 目的探讨HOXA11基因在子宫内膜单纯性增生和子宫内膜癌中表达的意义，以及与雌激素受体（estrogenic receptor，ER）、孕激素受体( progestogenic receptor，PR )表达的关系。方法用免疫组化法检测增生期子宫内膜、子宫内膜单纯性增生及子宫内膜癌的内膜组织中HOXA11、ER及PR蛋白的表达。结果在子宫内膜单纯性增生和内膜样腺癌中，HOXA11的表达明显高于增生期子宫内膜(P<0.05)，而ER、PR的表达明显低于增生期内膜(P<0.05)。结论 HOXA11的过度表达可能参与了子宫内膜异常增生或癌变的过程；这种效应可能与ER、PR表达下降相关。

Abstract: Objective TO examine HOXA11, ER and PR expression in human endometrial hyperplasia and adenocarcinoma. Methods The immunohistochemistry were applied to analyze the level of HOXA11、ER and PR expression in the proliferative endometria.，simple hyperplasia and endometrial adenocarcinoma .Results The expression levels of HOXA11 in the endometrial hyperplasia and adenocarcinoma were significantly higher than that of proliferative endometrium (P<0.05). Compared with proliferative endometrium, the expressions of ER and PR in the endometrial hyperplasia and adenocarcinoma were decreased(P<0.05). Conclusion Overexpression of HOXA11, which is associated with the decreased expression of ER and PR, and loss of down-regulated HOXA11 by progestogen, may participate in the program of abnormal proliferation or adenocarcinoma of the endometrium.

胡营营唐颖王莉芬吕丽王乃玉冯晓海堂远馨. HOXA11在子宫内膜单纯性增生和内膜癌中表达增加[J]. 基础医学与临床, 2007, 27(10): 1123-1126.

. Expression of HOXA 11 in human endometrial hyperplasia and adenocarcinoma[J]. Basic & Clinical Medicine, 2007, 27(10): 1123-1126.