基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 154-158.doi: 10.16352/j.issn.1001-6325.2022.01.030

• 短篇综述 • 上一篇    下一篇

人体生理参数参考区间的制定方法和应用

何慧婧, 单广良*   

  1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 流行病学与卫生统计学系, 北京 100005
  • 收稿日期:2020-11-12 修回日期:2021-04-09 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: * guangliang_shan@163.com
  • 基金资助:
    北京市自然科学基金(7204279); 科技部基础性工作专项(2013FY114100);国家自然科学基金(82003531)

Methodology and application of human physiological reference intervals estimation

HE Hui-jing, SHAN Guang-liang*   

  1. Department of Epidemiology and Statistics, Institute of Basic Medical Sciences CAMS; School of Basic Medicine PUMC, Beijing 100005, China
  • Received:2020-11-12 Revised:2021-04-09 Online:2022-01-05 Published:2022-01-05
  • Contact: * guangliang_shan@163.com

摘要: 生理参数参考区间(RI)估计对于健康评估、疾病筛查与诊断,以及治疗效果评价具有指导意义。目前中国尚无生理参数RI估计的方法学综述。本文拟通过对RI估计方法学的系统梳理,系统介绍生理参数RI制定的意义、方法和应用。RI估计方法主要有3类:非参数法、参数法和稳健估计法。研究者需结合研究目的和数据特点进行选择。本文可为制定生理参数RI提供方法学参考,也为实际工作中如何客观合理解读生理参数区间提供指导。

关键词: 参考区间, 生理参数, 方法学

Abstract: Establishment of physiological reference interval (RI) is important for health status evaluation, disease screening and diagnosis, and the effect assessment of clinical therapy. Currently, there is no review on methodology of RI establishment in China. Therefore, by reviewing of literatures on methodology of RI establishment, this article comprehensively described the purpose and significance of RI establishment,its statistical methods of calculation and its application. Three methods are commonly used for RI calculation: the nonparametric, parametric and robust estimate. Researchers may use a specific method based on research purpose and the characteristics of the data. This review provides methodological reference for RI establishment in China and also some guidelines to better understand the meaning of physiological constant RI in health practices.

Key words: reference interval, physiological constants, methodology

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