[1] RUBIN G M, LEWIS E B. A brief history of Drosophila′s contributions to genome research . Science, 2000, 287(5461):2216-2218.
[2] PANDEY U B, NICHOLS C D. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery . Pharmacol Rev, 2011, 63(2):411-436.
[3] GHOSH M, SONKAR S K, SAXENA M, et al. Carbon nano-onions for imaging the life cycle of Drosophila melanogaster . Small, 2011, 7(22):3170-3177.
[4] RAND M D. Drosophotoxicology:the growing potential for Drosophila in neurotoxicology . Neurotoxicol Teratol, 2010, 32(1):74-83.
[5] INAMDAR A A, CHAUDHURI A, O′DONNELL J. The protective effect of minocycline in a paraquat-induced Parkinson′s disease model in Drosophila is modified in altered genetic backgrounds . Parkinsons Dis, 2012, 2012:938528.
[6] HOWLETT I C, TANOUYE M A. Seizure-sensitivity in Drosophila is ameliorated by dorsal vessel injection of the antiepileptic drug valproate . J Neurogenet, 2013, 27(4):143-150.
[7] ADAMS M D, CELNIKER S E, HOLT R A, et al. The genome sequence of Drosophila melanogaster . Science, 2000, 287(5461):2185-2195.
[8] LLOYD T E, TAYLOR J P. Flightless flies:Drosophila models of neuromuscular disease . Ann N Y Acad Sci, 2010, 1184:e1-20.
[9] REITER L T, POTOCKI L, CHIEN S, et al. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster . Genome Res, 2001, 11(6):1114-1125.
SHEN L R, XIAO F, YUAN P, et al. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila . Age, 2013, 35(4):1133-1142.
NAVROTSKAYA V V, OXENKRUG G, VOROBYOVA L I, et al. Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster . Am J Plant Sci, 2012, 3(7A):1037-1040.
KIM M S. Korean red ginseng tonic extends lifespan in D. melanogaster . Biomol Ther, 2013, 21(3):241-245.
MORA M, BONILL E, MEDINA-LEENDERTZ S, et al. Minocycline increases the activity of superoxide dismutase and reduces the concentration of nitric oxide, hydrogen peroxide and mitochondrial malondialdehyde in manganese treated Drosophila melanogaster . Neurochem Res, 2014, 39(7):1270-1278.
LIN W S, CHEN J Y, WANG J C, et al. The anti-aging effects of ludwigiaoctovalvis on Drosophila melanogaster and SAMP8 mice . Age, 2014, 36(2):689-703.
HEINRICHSEN E T, HADDAD G G. Role of high-fat diet in stress response of Drosophila . PLoS One, 2012, 7(8):e42587.
BOYD O, WENG P, SUN X, et al. Nectarine promotes longevity in Drosophila melanogaster . Free Radic Biol Med, 2011, 50(11):1669-1678.
WANG C, WHEELER C T, ALBERICO T, et al. The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster . Age, 2013, 35(1):69-81.
CASTRO J P, CARARETO C M. Drosophila melanogaster P transposable elements:mechanisms of transposition and regulation . Genetica, 2004, 121(2):107-118.
BRAND A H, PERRIMON N. Targeted gene expression as a means of altering cellfates and generating dominant phenotypes . Development, 1993, 118(2):401-415.
LIU Y, ZHANG M C, WEI Y H, et al. The application of the GAL4/UAS system in the Drosophila Tis11RNA interference . Life Sci Res (生命科学研究), 2012, 16(3):207-211.
MUQIT M M, FEANY M B. Modelling neurodegenerative diseases in Drosophila:a fruitful approach? . Nat Rev Neurosci, 2002, 3(3):237-243.
WAN Y Q, XIE W. Drosophila:an important model organism for understanding basic biological and human disease mechanisms . Chin Bull Life Sci(生命科学), 2006, 18(5):425-429.
WILLIAMSON J, GOLDMAN J, MARDER K S. Genetic aspects of Alzheimer disease . Neurologist, 2009, 15(2):80-86.
YAARI R, COREY-BLOOM J. Alzheimer′s disease . Semin Neurol, 2007, 27(1):32-41.
VOSSEL K A, ZHANG K, BRODBECK J, et al. Tau reduction prevents Abeta-induced defects in axonal transport . Science, 2010, 330(6001):198.
WANG J J, WANG M, ZHANG L H, et al. Construction of Aβ42 transgenic AD flies and their applications in drug screening . Chin J Cell Biol(中国细胞生物学学报), 2014, 36(6):745-751.
WANG L, CHIANG H C, WU W, et al. Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss . Proc Natl Acad Sci USA, 2012, 109(41):16743-16748.
MHATRE S D, MICHELSON S J, GOMES J, et al. Development and characterization of an aged onset model of Alzheimer′s disease in Drosophila melanogaster . Exp Neurol, 2014, 261:772-781.
DUFFY J B. GAL4 system in Drosophila:a fly geneticist′s Swiss army knife . Genesis, 2002, 34(1-2):1-15.
WANG X, PERUMALSAMY H, KWON H W, et al. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer′s disease . Sci Rep, 2015, 5:16127.
POLYMEROPOULOS M H, LAVEDAN C, LEROY E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson′s disease . Science, 1997, 276(5321):2045-2047.
KITADA T, ASAKAWA S, HATTORI N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism . Nature, 1998, 392(6676):605-608.
BONIFATI V, RIZZU P, SQUITIERI F, et al. DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism . Neurol Sci, 2003, 24(3):159-160.
VALENTE E M, ABOU-SLEIMAN P M, CAPUTO V, et al. Hereditary early-onset Parkinson′s disease caused by mutations in PINK1 . Science, 2004, 304(5674):1158-1160.
PAISAN-RUIZ C, JAIN S, EVANS E W, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson′s disease . Neuron, 2004, 44(4):595-600.
RAGLAND M, HUTTER C, ZABETIAN C, et al. Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson′s disease:a HuGE review and Meta-analysis . Am J Epidemiol, 2009, 170(11):1344-1357.
KRUGER R, KUHN W, MULLER T, et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson′s disease . Nat Genet, 1998, 18(2):106-108.
SIDDIQUE Y H, NAZ F, JYOTI S. Effect of curcumin on lifespan, activity pattern, oxidative stress, and apoptosis in the brains of transgenic Drosophila model of Parkinson′s disease . Biomed Res Int, 2014, 2014:606928.
SIDDIQUE Y H, JYOTI S, NAZ F. Effect of epicatechingallate dietary supplementation on transgenic Drosophila model of Parkinson′s disease . J Diet Suppl, 2014, 11(2):121-130.
JANSEN R L, BROGAN B, WHITWORTH A J, et al. Effects of five ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson′s disease model . Phytother Res, 2014, 28(12):1789-1795.
HENDRICKS J C, KIRK D, PANCKERI K, et al. Modafinil maintains waking in the fruit fly drosophila melanogaster . Sleep, 2003, 26(2):139-146.
ANDRETIC R, KIM Y C, JONES F S, et al. Drosophila D1 dopamine receptor mediates caffeine-induced arousal . Proc Natl Acad Sci USA, 2008, 105(51):20392-20397.
YANG B, ZHANG A, SUN H, et al. Metabolomic study of insomnia and intervention effects of suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry . J Pharm Biomed Anal, 2012, 58:113-124.
YANG B, ZHANG A H, WANG H. The experimental study of suanzaorensaponin A, B in the treatment of insomnia based on Drosophila model . Inf Tradit Chin Med (中医药信息), 2013, 30(5):55-57.
GONZALEZ C. Drosophila melanogaster:a model and a tool to investigate malignancy and identify new therapeutics . Nat Rev Cancer, 2013, 13(3):172-183.
DAS T, CAGAN R. Drosophila as a novel therapeutic discovery tool for thyroid cancer . Thyroid, 2010, 20(7):689-695.
WILLOUGHBY L F, SCHLOSSER T, MANNING S A, et al. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery . Dis Model Mech, 2013, 6(2):521-529.
BIRSE R T, CHOI J, REARDON K, et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila . Cell Metab, 2010, 12(5):533-544.
CANAVOSO L E, JOUNI Z E, KARNAS K J, et al. Fat metabolism in insects . Annu Rev Nutr, 2001, 21:23-46.
PIAZZA N, WESSELLS R J. Drosophila models of cardiac disease . Prog Mol Biol Transl Sci, 2011, 100:155-210.