Analysis of Plasticizer in Compound Aluminum Hydroxide Tablets With GC-MS/MS
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Heilongjiang Institute for Food and Drug Control， Harbin 150001， China
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History+
Received
Revised
Published
2011-09-30
2011-09-30
2012-03-10
Issue Date
2012-04-14
Abstract
OBJECTIVE To develop GC/MS method in detect plasticizers in compound aluminum hydroxide tablets adsorbed from pharmaceutical packaging. METHODS The column： HP-5MS silica capillary column (30 m×0.25 μm，0.25 mm) was used； Ion source temperature was 230 ℃； Quadrupole temperature was 150 ℃； The total ion scanning rang： m/z 50～500. RESULTS The diethylhexyl phthafate linearity was in the range of 0.5-20.0 μg·mL-1 with a regression coefficient of 0.999 0. The average recovery of this method was 98.8%， and RSD was 1.4%. The RSD of intra-day and inter-day was 2.8% and 3.7% respectively. CONCLUSION This method is specificity， sensitive， and can be applied to detect and research DEHP which may be adsorbed or penetrated into drugs.
Analysis of Plasticizer in Compound Aluminum Hydroxide Tablets With GC-MS/MS[J]. Chinese Pharmaceutical Journal, 2012, 47(5): 384-386
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References
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