Effect of Vitamin K2 and Benazepril Combination Therapy on Gastric Cancer in Nude Mice

应卫星;陈华;李荣洲

Chinese Pharmaceutical Journal ›› 2012, Vol. 47 ›› Issue (3) : 186.

PDF(1001 KB)
PDF(1001 KB)
Chinese Pharmaceutical Journal ›› 2012, Vol. 47 ›› Issue (3) : 186.
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Effect of Vitamin K2 and Benazepril Combination Therapy on Gastric Cancer in Nude Mice

  • 应卫星a,陈华b,李荣洲a
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Abstract

OBJECTIVE To investigate the effect of vitamin K2 combined with benazepril on human gastric cancer in nude mice.METHODS SGC-7901 human gastric cancer cells were implanted into BALB/c nude mice to establish the cancer model. Fourteen days after the subcutaneous implantation of cancer cells,40 nude mice were randomly divided into 4 groups: control group, vitamin K2 therapy group, benazepril therapy group and combination therapy group (vitamin K2+ benazepril). After 14 d, the tumor growth was evaluated, apoptosis indices were examined by TUNEL assay, and VEGF and caspase 3 expression were assessed by immunohistochemical staining. RESULTS Compared to the control group, tumor weights were decreased and apoptosis indexes was significantly increased in the therapy groups (P

Key words

vitamin K2|benazepril|apoptosis|vascular endothelial growth factor|gastric cancinoma

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应卫星;陈华;李荣洲. Effect of Vitamin K2 and Benazepril Combination Therapy on Gastric Cancer in Nude Mice[J]. Chinese Pharmaceutical Journal, 2012, 47(3): 186
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