OBJECTIVE To establish a method for determination of 30 antihypertensive medicines adulterated in traditional Chinese patent medicines and health foods by UPLC triple-quadrupole tandem mass spectrometer. METHODS Multi-reactions monitoring (MRM) technology was used. The separation was performed on a Waters ACQUITY UPLC^TM BEH C₁₈ column with a gradient mobile phase of methanol - 0.1% formic acid at flow rate of 0.2 mL·min^-1. The ionization mode was ESI⁺. RESULTS The standard curves of the 30 chemical medicines showed good linearity over the concentration ranges of 10-1 000.0 ， 0-400.0 and 2.0-400.0 μg·L^-1 (r=0.990 3-0.999 8). The detection limits of the 30 chemical medicines were between 0.01-0.83 μg·L^-1 and the average recoveries were 72.2%-123.4% at 3 levels. CONCLUSION The method is rapid and sensitive， and suitable for the determination of 30 chemical medicines in traditional Chinese patent medicines and health foods.